Revista da Sociedade Brasileira de Medicina Tropical (Feb 2019)

TGF-β1 polymorphism in American tegumentary leishmaniasis in a Southern Brazilian population

  • Fabiane Vieira Berg Shehadeh,
  • Rosiane Ribeiro dos Santos,
  • Laiane Alzira Denski da Silva,
  • Waldir Veríssimo da Silva Júnior,
  • Rejane Ribas-Silva,
  • Adriana Danmvolf Ribas,
  • Thaís Gomes Verzignassi Silveira,
  • Sueli Donizete Borelli,
  • Sandra Mara Alessi Aristides

DOI
https://doi.org/10.1590/0037-8682-0415-2017
Journal volume & issue
Vol. 52, no. 0

Abstract

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Abstract INTRODUCTION: Genetic polymorphisms define the cytokine production leading to susceptibility or resistance to diseases. We studied the cytokine polymorphism in the development of tegumentary leishmaniasis (TL). METHODS: Genotyping of TNF-α, TGF-β1, IFN-γ, IL-6, and IL-10 were performed by polymerase chain reaction assay. RESULTS: G and C alleles of TGF- β1 (codon 25) were the most common in controls and patients, respectively. G/G was the most frequent genotype in controls, and G/C and C/C in patients. CONCLUSIONS: G/G genotype of codon 25 in TGF-β1 appeared to confer resistance, and G/C and C/C genotypes, susceptibility to TL in this population.

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