Nature Communications (Apr 2020)
Lgr5+ telocytes are a signaling source at the intestinal villus tip
- Keren Bahar Halpern,
- Hassan Massalha,
- Rachel K. Zwick,
- Andreas E. Moor,
- David Castillo-Azofeifa,
- Milena Rozenberg,
- Lydia Farack,
- Adi Egozi,
- Dan R. Miller,
- Inna Averbukh,
- Yotam Harnik,
- Noa Weinberg-Corem,
- Frederic J. de Sauvage,
- Ido Amit,
- Ophir D. Klein,
- Michal Shoshkes-Carmel,
- Shalev Itzkovitz
Affiliations
- Keren Bahar Halpern
- Department of Molecular Cell Biology, Weizmann Institute of Science
- Hassan Massalha
- Department of Molecular Cell Biology, Weizmann Institute of Science
- Rachel K. Zwick
- Program in Craniofacial Biology and Department of Orofacial Sciences, University of California
- Andreas E. Moor
- Institute of Molecular Cancer Research, University of Zurich
- David Castillo-Azofeifa
- Program in Craniofacial Biology and Department of Orofacial Sciences, University of California
- Milena Rozenberg
- Department of Molecular Cell Biology, Weizmann Institute of Science
- Lydia Farack
- Department of Molecular Cell Biology, Weizmann Institute of Science
- Adi Egozi
- Department of Molecular Cell Biology, Weizmann Institute of Science
- Dan R. Miller
- Department of Molecular Cell Biology, Weizmann Institute of Science
- Inna Averbukh
- Department of Molecular Cell Biology, Weizmann Institute of Science
- Yotam Harnik
- Department of Molecular Cell Biology, Weizmann Institute of Science
- Noa Weinberg-Corem
- Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University Hadassah Medical School
- Frederic J. de Sauvage
- Department of Molecular Oncology, Genentech
- Ido Amit
- Department of Immunology, Weizmann Institute of Science
- Ophir D. Klein
- Program in Craniofacial Biology and Department of Orofacial Sciences, University of California
- Michal Shoshkes-Carmel
- Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University Hadassah Medical School
- Shalev Itzkovitz
- Department of Molecular Cell Biology, Weizmann Institute of Science
- DOI
- https://doi.org/10.1038/s41467-020-15714-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Epithelial gene expression has been shown to be zonated along the crypt-villus axis, but mechanisms shaping this spatial variability were unknown. Here, Bahar Halpern et al. uncover zonation of mesenchymal cells, including Lgr5+ telocytes, which regulate epithelial gene expression at the villus tip.
