Bulletin of Chemical Reaction Engineering & Catalysis (Apr 2018)

Microwave Assisted Expeditious and Green Cu(II)-Clay Catalyzed Domino One-Pot Three Component Synthesis of 2H-indazoles

  • Bashir Ahmad Dar,
  • Syed Wasim Safvi,
  • Masood Ahmad Rizvi

DOI
https://doi.org/10.9767/bcrec.13.1.963.82-88
Journal volume & issue
Vol. 13, no. 1
pp. 82 – 88

Abstract

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A simple and efficient synthesis of 2H-indazoles is achieved from 2-primary amines, bromobenzaldehydes and sodium azide through domino condensation, C–N and N–N bond formations, catalyzed by a heterogeneous Cu(II)-Clay catalyst. The recyclable heterogeneous Cu(II)-Clay catalyst exhibited a remarkable activity for the title reaction without any additives. An assortment of structurally diverse 2H-indazoles were prepared in good to excellent yields from easily available starting materials by using this protocol. The Cu(II)-Clay catalyst was characterized by using X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), and Brunauer-Emmett-Teller (BET) techniques.

Keywords