Nature Communications (Sep 2022)
Fatty acid metabolism in aggressive B-cell lymphoma is inhibited by tetraspanin CD37
- Rens Peeters,
- Jorge Cuenca-Escalona,
- Esther A. Zaal,
- Anna T. Hoekstra,
- Anouk C. G. Balvert,
- Marcos Vidal-Manrique,
- Niek Blomberg,
- Sjoerd J. van Deventer,
- Rinke Stienstra,
- Julia Jellusova,
- Martin Giera,
- Luciana Hannibal,
- Ute Spiekerkoetter,
- Martin ter Beest,
- Celia R. Berkers,
- Annemiek B. van Spriel
Affiliations
- Rens Peeters
- Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre
- Jorge Cuenca-Escalona
- Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre
- Esther A. Zaal
- Division of Cell Biology, Metabolism & Cancer, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University
- Anna T. Hoekstra
- Biomolecular Mass Spectrometry and Proteomics, Bijvoet Centre for Biomolecular Research, Utrecht University
- Anouk C. G. Balvert
- Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre
- Marcos Vidal-Manrique
- Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre
- Niek Blomberg
- Metabolics Group, Leiden University Medical Centre
- Sjoerd J. van Deventer
- Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre
- Rinke Stienstra
- Human Nutrition and Health, Wageningen University
- Julia Jellusova
- Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine, Klinikum rechts der Isar, Technical University Munich
- Martin Giera
- Metabolics Group, Leiden University Medical Centre
- Luciana Hannibal
- Laboratory of Clinical Biochemistry and Metabolism, Department of General Paediatrics, Adolescent Medicine and Neonatology, Faculty of Medicine, Medical Centre - University of Freiburg
- Ute Spiekerkoetter
- Department of General Pediatrics, Adolescent Medicine and Neonatology, Faculty of Medicine, Medical Centre - University of Freiburg
- Martin ter Beest
- Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre
- Celia R. Berkers
- Division of Cell Biology, Metabolism & Cancer, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University
- Annemiek B. van Spriel
- Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre
- DOI
- https://doi.org/10.1038/s41467-022-33138-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Tetraspanin CD37 deficiency has been reported as a prognostic marker for aggressive B-cell lymphoma. Here, the authors show that CD37 interacts with the fatty acid transporter 1 to inhibit palmitate uptake and its deficiency leads to increased fatty acid metabolism which promotes tumorigenesis in B-cell lymphoma.
