Nature Communications (May 2018)

Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain

  • Ulrike Scheib,
  • Matthias Broser,
  • Oana M. Constantin,
  • Shang Yang,
  • Shiqiang Gao,
  • Shatanik Mukherjee,
  • Katja Stehfest,
  • Georg Nagel,
  • Christine E. Gee,
  • Peter Hegemann

DOI
https://doi.org/10.1038/s41467-018-04428-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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Cyclic AMP and cGMP orchestrate a variety of cellular responses. Here, authors characterize the cGMP producing rhodopsin-guanylyl cyclase from C. anguillulae and derived adenylyl cyclase by a biochemical and structural approach which demonstrates the usability of these cyclases for optogenetic applications.