mBio (Apr 2021)
Markers of Polyfunctional SARS-CoV-2 Antibodies in Convalescent Plasma
- Harini Natarajan,
- Andrew R. Crowley,
- Savannah E. Butler,
- Shiwei Xu,
- Joshua A. Weiner,
- Evan M. Bloch,
- Kirsten Littlefield,
- Wendy Wieland-Alter,
- Ruth I. Connor,
- Peter F. Wright,
- Sarah E. Benner,
- Tania S. Bonny,
- Oliver Laeyendecker,
- David Sullivan,
- Shmuel Shoham,
- Thomas C. Quinn,
- H. Benjamin Larman,
- Arturo Casadevall,
- Andrew Pekosz,
- Andrew D. Redd,
- Aaron A. R. Tobian,
- Margaret E. Ackerman
Affiliations
- Harini Natarajan
- Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, New Hampshire, USA
- Andrew R. Crowley
- Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, New Hampshire, USA
- Savannah E. Butler
- Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, New Hampshire, USA
- Shiwei Xu
- Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA
- Joshua A. Weiner
- Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA
- Evan M. Bloch
- Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
- Kirsten Littlefield
- W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
- Wendy Wieland-Alter
- Department of Pediatrics, Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA
- Ruth I. Connor
- Department of Pediatrics, Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA
- Peter F. Wright
- Department of Pediatrics, Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA
- Sarah E. Benner
- Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
- Tania S. Bonny
- Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
- Oliver Laeyendecker
- ORCiD
- Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
- David Sullivan
- W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
- Shmuel Shoham
- Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
- Thomas C. Quinn
- Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
- H. Benjamin Larman
- Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
- Arturo Casadevall
- ORCiD
- W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
- Andrew Pekosz
- ORCiD
- W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
- Andrew D. Redd
- Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
- Aaron A. R. Tobian
- Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
- Margaret E. Ackerman
- ORCiD
- Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, New Hampshire, USA
- DOI
- https://doi.org/10.1128/mBio.00765-21
- Journal volume & issue
-
Vol. 12,
no. 2
Abstract
Convalescent plasma has been deployed globally as a treatment for COVID-19, but efficacy has been mixed. Better understanding of the antibody characteristics that may contribute to its antiviral effects is important for this intervention as well as offer insights into correlates of vaccine-mediated protection.
