Sarcoma (Jan 1998)

Outcome and Toxicity of an Ifosfamide-Based Soft Tissue Sarcoma Treatment Protocol in Children. The Importance of Local Therapy

  • S. Murray Yule,
  • Roderick Skinner,
  • Martin W. English,
  • Mike Cole,
  • Andrew D. J. Pearson,
  • Helen H. Lucraft,
  • Alan W. Craft

DOI
https://doi.org/10.1080/13577149877939
Journal volume & issue
Vol. 2, no. 3-4
pp. 171 – 177

Abstract

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Background. Although the survival of children with soft tissue sarcoma (STS) has improved considerably, the outcome of patients with metastatic disease, and those with primary tumours of the extremities or parameningeal sites remains disappointing. We describe the clinical outcome of an ifosfamide-based regimen with local therapy directed only to children who failed to achieve a complete response to initial chemotherapy.