Nature Communications (Jan 2018)
Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo
- Masayuki Furuya,
- Junichi Kikuta,
- Sayumi Fujimori,
- Shigeto Seno,
- Hiroki Maeda,
- Mai Shirazaki,
- Maki Uenaka,
- Hiroki Mizuno,
- Yoriko Iwamoto,
- Akito Morimoto,
- Kunihiko Hashimoto,
- Takeshi Ito,
- Yukihiro Isogai,
- Masafumi Kashii,
- Takashi Kaito,
- Shinsuke Ohba,
- Ung-il Chung,
- Alexander C. Lichtler,
- Kazuya Kikuchi,
- Hideo Matsuda,
- Hideki Yoshikawa,
- Masaru Ishii
Affiliations
- Masayuki Furuya
- Department of Immunology and Cell Biology, Graduate School of Medicine & Frontier Biosciences, Osaka University
- Junichi Kikuta
- Department of Immunology and Cell Biology, Graduate School of Medicine & Frontier Biosciences, Osaka University
- Sayumi Fujimori
- Department of Cellular Dynamics, WPI-Immunology Frontier Research Center, Osaka University
- Shigeto Seno
- Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University
- Hiroki Maeda
- Department of Material and Life Sciences, Graduate School of Engineering, Osaka University
- Mai Shirazaki
- Department of Immunology and Cell Biology, Graduate School of Medicine & Frontier Biosciences, Osaka University
- Maki Uenaka
- Department of Immunology and Cell Biology, Graduate School of Medicine & Frontier Biosciences, Osaka University
- Hiroki Mizuno
- Department of Immunology and Cell Biology, Graduate School of Medicine & Frontier Biosciences, Osaka University
- Yoriko Iwamoto
- Department of Immunology and Cell Biology, Graduate School of Medicine & Frontier Biosciences, Osaka University
- Akito Morimoto
- Department of Immunology and Cell Biology, Graduate School of Medicine & Frontier Biosciences, Osaka University
- Kunihiko Hashimoto
- Department of Immunology and Cell Biology, Graduate School of Medicine & Frontier Biosciences, Osaka University
- Takeshi Ito
- Laboratory for Pharmacology, Pharmaceutical Research Center, Asahi Kasei Pharma Corporation
- Yukihiro Isogai
- Medical Affairs Department, Pharmaceutical Business Administration Division, Asahi Kasei Pharma Corporation
- Masafumi Kashii
- Department of Orthopaedics, Graduate School of Medicine, Osaka University
- Takashi Kaito
- Department of Orthopaedics, Graduate School of Medicine, Osaka University
- Shinsuke Ohba
- Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, The University of Tokyo
- Ung-il Chung
- Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, The University of Tokyo
- Alexander C. Lichtler
- Department of Reconstructive Sciences, School of Dental Medicine, University of Connecticut Health Center
- Kazuya Kikuchi
- Department of Material and Life Sciences, Graduate School of Engineering, Osaka University
- Hideo Matsuda
- Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University
- Hideki Yoshikawa
- Department of Orthopaedics, Graduate School of Medicine, Osaka University
- Masaru Ishii
- Department of Immunology and Cell Biology, Graduate School of Medicine & Frontier Biosciences, Osaka University
- DOI
- https://doi.org/10.1038/s41467-017-02541-w
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Communication between osteoblasts and osteoclasts is essential for bone homeostasis, but the mode of interaction is unclear. The authors use intravital two-photon microscopy in mice to show that these cells directly interact, regulating activity of osteoclasts, and that the interaction is modulated by parathyroid hormone administration.
