Impact of trisomy 8 and deletion 17p on leukemic transformation in patients with essential thrombocythemia receiving hydroxyurea treatment

Abstract

Hydoxyuera has been widely used in treatment of patients with essential thrombocythemia (ET). There is a lack of definitive information about it's leukomogenic potential. Choromosomal abnormalities are found to be rare at diagnosis in ET patients. Here we present a case who had trisomy 8 at diagnosis and developed P53 mutation under hydroxyurea treatment. Blastic transformation occurred very soon after arising of P53 mutation. Case was discussed based on the current literature knowledge.

Keywords

• Essential Thrombocythemia
• hydroxyurea treatment
• p53
• trisomy 8