Pyrazinamide Induced Polyarthralgia and Myalgia in a Case of Pulmonary Tuberculosis – A Case Report

Abstract

Pyrazinamide Induced polyarthralgia is common but myalgia is an uncommon adverse drug reaction. Understanding a case with estimated peak plasma concentration correlation is very rarely performed. We describe a case of 45 year old female patient with pulmonary tuberculosis who developed polyarthralgia and myalgia with the standard dose of pyrazinamide in a fixed-dose antitubercular regimen. She had an estimated peak plasma concentration of 48.2 μg/ml which was in the upper limit of the normal range of proposed therapeutic range for pyrazinamide. She had increased levels of serum uric acid and creatine kinase. Resolution in polyarthralgia was observed within 14 days of pyrazinamide dechallenge. However, resolution in myalgia was delayed.

Keywords

• pulmonary tuberculosis
• pyrazinamide
• polyarthralgia
• myalgia