Nature Communications (Mar 2020)
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity
- Camilla Calandrini,
- Frans Schutgens,
- Rurika Oka,
- Thanasis Margaritis,
- Tito Candelli,
- Luka Mathijsen,
- Carola Ammerlaan,
- Ravian L. van Ineveld,
- Sepide Derakhshan,
- Sanne de Haan,
- Emmy Dolman,
- Philip Lijnzaad,
- Lars Custers,
- Harry Begthel,
- Hindrik H. D. Kerstens,
- Lindy L. Visser,
- Maarten Rookmaaker,
- Marianne Verhaar,
- Godelieve A. M. Tytgat,
- Patrick Kemmeren,
- Ronald R. de Krijger,
- Reem Al-Saadi,
- Kathy Pritchard-Jones,
- Marcel Kool,
- Anne C. Rios,
- Marry M. van den Heuvel-Eibrink,
- Jan J. Molenaar,
- Ruben van Boxtel,
- Frank C. P. Holstege,
- Hans Clevers,
- Jarno Drost
Affiliations
- Camilla Calandrini
- Oncode Institute, Princess Máxima Center for Pediatric Oncology
- Frans Schutgens
- Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center
- Rurika Oka
- Oncode Institute, Princess Máxima Center for Pediatric Oncology
- Thanasis Margaritis
- Princess Máxima Center for Pediatric Oncology
- Tito Candelli
- Princess Máxima Center for Pediatric Oncology
- Luka Mathijsen
- Oncode Institute, Princess Máxima Center for Pediatric Oncology
- Carola Ammerlaan
- Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center
- Ravian L. van Ineveld
- Oncode Institute, Princess Máxima Center for Pediatric Oncology
- Sepide Derakhshan
- Oncode Institute, Princess Máxima Center for Pediatric Oncology
- Sanne de Haan
- Oncode Institute, Princess Máxima Center for Pediatric Oncology
- Emmy Dolman
- Princess Máxima Center for Pediatric Oncology
- Philip Lijnzaad
- Princess Máxima Center for Pediatric Oncology
- Lars Custers
- Oncode Institute, Princess Máxima Center for Pediatric Oncology
- Harry Begthel
- Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center
- Hindrik H. D. Kerstens
- Princess Máxima Center for Pediatric Oncology
- Lindy L. Visser
- Princess Máxima Center for Pediatric Oncology
- Maarten Rookmaaker
- University Medical Center, Department of Nephrology and Hypertension
- Marianne Verhaar
- University Medical Center, Department of Nephrology and Hypertension
- Godelieve A. M. Tytgat
- Princess Máxima Center for Pediatric Oncology
- Patrick Kemmeren
- Princess Máxima Center for Pediatric Oncology
- Ronald R. de Krijger
- Princess Máxima Center for Pediatric Oncology
- Reem Al-Saadi
- University College London, UCL Great Ormond Street Institute of Child Health
- Kathy Pritchard-Jones
- University College London, UCL Great Ormond Street Institute of Child Health
- Marcel Kool
- Princess Máxima Center for Pediatric Oncology
- Anne C. Rios
- Oncode Institute, Princess Máxima Center for Pediatric Oncology
- Marry M. van den Heuvel-Eibrink
- Princess Máxima Center for Pediatric Oncology
- Jan J. Molenaar
- Princess Máxima Center for Pediatric Oncology
- Ruben van Boxtel
- Oncode Institute, Princess Máxima Center for Pediatric Oncology
- Frank C. P. Holstege
- Princess Máxima Center for Pediatric Oncology
- Hans Clevers
- Oncode Institute, Princess Máxima Center for Pediatric Oncology
- Jarno Drost
- Oncode Institute, Princess Máxima Center for Pediatric Oncology
- DOI
- https://doi.org/10.1038/s41467-020-15155-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Pre-clinical cell culture models capturing the heterogeneity of childhood kidney tumours are limited. Here, the authors establish and characterise an organoid biobank of tumour and matched normal organoid cultures from over 50 children with different subtypes of kidney cancer.
