TPGS-based and S-thanatin functionalized nanorods for overcoming drug resistance in Klebsiella pneumonia

Xiaojuan Wang; Xiaoling Xu; Shaojun Zhang; Na Chen; Yunfeng Sun; Kuifen Ma; Dongsheng Hong; Lu Li; Yongzhong Du; Xiaoyang Lu; Saiping Jiang

doi:10.1038/s41467-022-31500-3

Nature Communications (Jun 2022)

TPGS-based and S-thanatin functionalized nanorods for overcoming drug resistance in Klebsiella pneumonia

Xiaojuan Wang,
Xiaoling Xu,
Shaojun Zhang,
Na Chen,
Yunfeng Sun,
Kuifen Ma,
Dongsheng Hong,
Lu Li,
Yongzhong Du,
Xiaoyang Lu,
Saiping Jiang

Affiliations

Xiaojuan Wang: Department of Clinical Pharmacy, The First Affiliated Hospital, School of Medicine, Zhejiang University
Xiaoling Xu: Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University
Shaojun Zhang: Department of Clinical Pharmacy, The First Affiliated Hospital, School of Medicine, Zhejiang University
Na Chen: Department of Clinical Pharmacy, The First Affiliated Hospital, School of Medicine, Zhejiang University
Yunfeng Sun: Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University
Kuifen Ma: Department of Clinical Pharmacy, The First Affiliated Hospital, School of Medicine, Zhejiang University
Dongsheng Hong: Department of Clinical Pharmacy, The First Affiliated Hospital, School of Medicine, Zhejiang University
Lu Li: Department of Clinical Pharmacy, The First Affiliated Hospital, School of Medicine, Zhejiang University
Yongzhong Du: Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University
Xiaoyang Lu: Department of Clinical Pharmacy, The First Affiliated Hospital, School of Medicine, Zhejiang University
Saiping Jiang: Department of Clinical Pharmacy, The First Affiliated Hospital, School of Medicine, Zhejiang University

DOI: https://doi.org/10.1038/s41467-022-31500-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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Overproduction of efflux pumps represents an important mechanism of Klebsiella pneumonia resistance to tigecycline. Here, the authors design TPGS- and S-thanatin functionalized nanorods loaded with tigecycline to increase drug accumulation inside bacteria and overcome bacterial resistance.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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