Nature Communications (Aug 2021)
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
- Athea Vichas,
- Amanda K. Riley,
- Naomi T. Nkinsi,
- Shriya Kamlapurkar,
- Phoebe C. R. Parrish,
- April Lo,
- Fujiko Duke,
- Jennifer Chen,
- Iris Fung,
- Jacqueline Watson,
- Matthew Rees,
- Austin M. Gabel,
- James D. Thomas,
- Robert K. Bradley,
- John K. Lee,
- Emily M. Hatch,
- Marina K. Baine,
- Natasha Rekhtman,
- Marc Ladanyi,
- Federica Piccioni,
- Alice H. Berger
Affiliations
- Athea Vichas
- Human Biology Division, Fred Hutchinson Cancer Research Center
- Amanda K. Riley
- Human Biology Division, Fred Hutchinson Cancer Research Center
- Naomi T. Nkinsi
- Human Biology Division, Fred Hutchinson Cancer Research Center
- Shriya Kamlapurkar
- Human Biology Division, Fred Hutchinson Cancer Research Center
- Phoebe C. R. Parrish
- Human Biology Division, Fred Hutchinson Cancer Research Center
- April Lo
- Human Biology Division, Fred Hutchinson Cancer Research Center
- Fujiko Duke
- Broad Institute of MIT & Harvard
- Jennifer Chen
- Broad Institute of MIT & Harvard
- Iris Fung
- Broad Institute of MIT & Harvard
- Jacqueline Watson
- Broad Institute of MIT & Harvard
- Matthew Rees
- Broad Institute of MIT & Harvard
- Austin M. Gabel
- Department of Genome Sciences, University of Washington
- James D. Thomas
- Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center
- Robert K. Bradley
- Department of Genome Sciences, University of Washington
- John K. Lee
- Human Biology Division, Fred Hutchinson Cancer Research Center
- Emily M. Hatch
- Human Biology Division, Fred Hutchinson Cancer Research Center
- Marina K. Baine
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Natasha Rekhtman
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Marc Ladanyi
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Federica Piccioni
- Broad Institute of MIT & Harvard
- Alice H. Berger
- Human Biology Division, Fred Hutchinson Cancer Research Center
- DOI
- https://doi.org/10.1038/s41467-021-24841-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
RIT1 mutations are mutually exclusive with other lung cancer drivers and lack targeted therapies. Here the authors examine genetic dependencies of mutant RIT1 with genome-wide CRISPR screens, revealing synergy between RIT1 and YAP1, and increased sensitivity to Aurora kinase inhibitors.
