Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal

Li Du; Yi-Jia Li; Marwan Fakih; Rebecca L. Wiatrek; Marjun Duldulao; Zhenbin Chen; Peiguo Chu; Julio Garcia-Aguilar; Yuan Chen

doi:10.1038/ncomms12326

Nature Communications (Jul 2016)

Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal

Li Du,
Yi-Jia Li,
Marwan Fakih,
Rebecca L. Wiatrek,
Marjun Duldulao,
Zhenbin Chen,
Peiguo Chu,
Julio Garcia-Aguilar,
Yuan Chen

Affiliations

Li Du: Department of Molecular Medicine, Beckman Research Institute of City of Hope
Yi-Jia Li: Department of Molecular Medicine, Beckman Research Institute of City of Hope
Marwan Fakih: Department of Medical Oncology, City of Hope National Medical Center
Rebecca L. Wiatrek: Department of Surgery, City of Hope National Medical Center
Marjun Duldulao: Department of Surgery, City of Hope National Medical Center
Zhenbin Chen: Department of Surgery, City of Hope National Medical Center
Peiguo Chu: Department of Pathology, City of Hope National Medical Center
Julio Garcia-Aguilar: Department of Surgery, City of Hope National Medical Center
Yuan Chen: Department of Molecular Medicine, Beckman Research Institute of City of Hope

DOI: https://doi.org/10.1038/ncomms12326
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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Cancer stem cells (CSCs) have key roles in tumor initiation and metastasis. Here, the authors show that the SUMO E1 and global sumoylation levels are high in colorectal CSCs and that depletion of the catalytic subunit of the SUMO E1, SAE2, affects CSCs self-renewal through TRIM21-mediated degradation of the Oct1, a transcription factor for ALDH.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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