Nature Communications (Aug 2019)
Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease
Abstract
Dysregulation of intracellular calcium is reported in Alzheimer’s disease. Here the authors show that loss of the mitochondrial Na+ /Ca2 + exchanger, NCLX – primary route of mitochondrial calcium efflux, precedes neuronal pathology in experimental models and contributes to Alzheimer’s disease progression.