NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance

Rose Hodgson; Xijin Xu; Consuelo Anzilotti; Mukta Deobagkar-Lele; Tanya L. Crockford; Jessica D. Kepple; Eleanor Cawthorne; Aneesha Bhandari; Alberto Cebrian-Serrano; Martin J. Wilcock; Benjamin Davies; Richard J. Cornall; Katherine R. Bull

doi:10.1038/s42003-022-04118-w

Communications Biology (Nov 2022)

NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance

Rose Hodgson,
Xijin Xu,
Consuelo Anzilotti,
Mukta Deobagkar-Lele,
Tanya L. Crockford,
Jessica D. Kepple,
Eleanor Cawthorne,
Aneesha Bhandari,
Alberto Cebrian-Serrano,
Martin J. Wilcock,
Benjamin Davies,
Richard J. Cornall,
Katherine R. Bull

Affiliations

Rose Hodgson: MRC Human Immunology Unit, Nuffield Department of Medicine, University of Oxford
Xijin Xu: MRC Human Immunology Unit, Nuffield Department of Medicine, University of Oxford
Consuelo Anzilotti: MRC Human Immunology Unit, Nuffield Department of Medicine, University of Oxford
Mukta Deobagkar-Lele: MRC Human Immunology Unit, Nuffield Department of Medicine, University of Oxford
Tanya L. Crockford: MRC Human Immunology Unit, Nuffield Department of Medicine, University of Oxford
Jessica D. Kepple: Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford
Eleanor Cawthorne: MRC Human Immunology Unit, Nuffield Department of Medicine, University of Oxford
Aneesha Bhandari: MRC Human Immunology Unit, Nuffield Department of Medicine, University of Oxford
Alberto Cebrian-Serrano: Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford
Martin J. Wilcock: MRC Human Immunology Unit, Nuffield Department of Medicine, University of Oxford
Benjamin Davies: Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford
Richard J. Cornall: MRC Human Immunology Unit, Nuffield Department of Medicine, University of Oxford
Katherine R. Bull: MRC Human Immunology Unit, Nuffield Department of Medicine, University of Oxford

DOI: https://doi.org/10.1038/s42003-022-04118-w
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 14

Abstract

Read online

Despite an upregulation in anergic B cells, N-myc downstream-regulated gene 1 (NDRG1) is not required for the tolerogenic downstream responses, reducing risk of immune modulation on targeting of NDRG1 for cancer therapeutics.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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