Nature Communications (Jan 2022)
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19
- Avraham Unterman,
- Tomokazu S. Sumida,
- Nima Nouri,
- Xiting Yan,
- Amy Y. Zhao,
- Victor Gasque,
- Jonas C. Schupp,
- Hiromitsu Asashima,
- Yunqing Liu,
- Carlos Cosme,
- Wenxuan Deng,
- Ming Chen,
- Micha Sam Brickman Raredon,
- Kenneth B. Hoehn,
- Guilin Wang,
- Zuoheng Wang,
- Giuseppe DeIuliis,
- Neal G. Ravindra,
- Ningshan Li,
- Christopher Castaldi,
- Patrick Wong,
- John Fournier,
- Santos Bermejo,
- Lokesh Sharma,
- Arnau Casanovas-Massana,
- Chantal B. F. Vogels,
- Anne L. Wyllie,
- Nathan D. Grubaugh,
- Anthony Melillo,
- Hailong Meng,
- Yan Stein,
- Maksym Minasyan,
- Subhasis Mohanty,
- William E. Ruff,
- Inessa Cohen,
- Khadir Raddassi,
- The Yale IMPACT Research Team,
- Laura E. Niklason,
- Albert I. Ko,
- Ruth R. Montgomery,
- Shelli F. Farhadian,
- Akiko Iwasaki,
- Albert C. Shaw,
- David van Dijk,
- Hongyu Zhao,
- Steven H. Kleinstein,
- David A. Hafler,
- Naftali Kaminski,
- Charles S. Dela Cruz
Affiliations
- Avraham Unterman
- Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University
- Tomokazu S. Sumida
- Department of Neurology, School of Medicine, Yale University
- Nima Nouri
- Department of Pathology, Yale School of Medicine
- Xiting Yan
- Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University
- Amy Y. Zhao
- Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University
- Victor Gasque
- Department of Computer Science, Yale University
- Jonas C. Schupp
- Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University
- Hiromitsu Asashima
- Department of Neurology, School of Medicine, Yale University
- Yunqing Liu
- Department of Biostatistics, Yale School of Public Health, Yale University
- Carlos Cosme
- Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University
- Wenxuan Deng
- Department of Biostatistics, Yale School of Public Health, Yale University
- Ming Chen
- Department of Biostatistics, Yale School of Public Health, Yale University
- Micha Sam Brickman Raredon
- Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University
- Kenneth B. Hoehn
- Department of Pathology, Yale School of Medicine
- Guilin Wang
- Yale Center for Genome Analysis/Keck Biotechnology Resource Laboratory, Department of Molecular Biophysics and Biochemistry, Yale School of Medicine
- Zuoheng Wang
- Department of Biostatistics, Yale School of Public Health, Yale University
- Giuseppe DeIuliis
- Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University
- Neal G. Ravindra
- Department of Computer Science, Yale University
- Ningshan Li
- Department of Biostatistics, Yale School of Public Health, Yale University
- Christopher Castaldi
- Yale Center for Genome Analysis, Yale School of Medicine
- Patrick Wong
- Department of Immunobiology, School of Medicine, Yale University
- John Fournier
- School of Medicine, Yale University
- Santos Bermejo
- Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University
- Lokesh Sharma
- Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University
- Arnau Casanovas-Massana
- Department of Epidemiology of Microbial Diseases, Yale School of Public Health
- Chantal B. F. Vogels
- Department of Epidemiology of Microbial Diseases, Yale School of Public Health
- Anne L. Wyllie
- Department of Epidemiology of Microbial Diseases, Yale School of Public Health
- Nathan D. Grubaugh
- Department of Epidemiology of Microbial Diseases, Yale School of Public Health
- Anthony Melillo
- Department of Pathology, Yale School of Medicine
- Hailong Meng
- Department of Pathology, Yale School of Medicine
- Yan Stein
- Pulmonary Institute, Tel Aviv Sourasky Medical Center, Tel Aviv University
- Maksym Minasyan
- Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University
- Subhasis Mohanty
- Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, Yale University
- William E. Ruff
- Department of Neurology, School of Medicine, Yale University
- Inessa Cohen
- Department of Neurology, School of Medicine, Yale University
- Khadir Raddassi
- Department of Neurology, School of Medicine, Yale University
- The Yale IMPACT Research Team
- Laura E. Niklason
- Departments of Anesthesiology & Biomedical Engineering, Yale University
- Albert I. Ko
- Department of Epidemiology of Microbial Diseases, Yale School of Public Health
- Ruth R. Montgomery
- Department of Internal Medicine, Yale School of Medicine
- Shelli F. Farhadian
- Department of Neurology, School of Medicine, Yale University
- Akiko Iwasaki
- Department of Immunobiology, School of Medicine, Yale University
- Albert C. Shaw
- Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, Yale University
- David van Dijk
- Department of Computer Science, Yale University
- Hongyu Zhao
- Department of Biostatistics, Yale School of Public Health, Yale University
- Steven H. Kleinstein
- Department of Immunobiology, School of Medicine, Yale University
- David A. Hafler
- Department of Neurology, School of Medicine, Yale University
- Naftali Kaminski
- Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University
- Charles S. Dela Cruz
- Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University
- DOI
- https://doi.org/10.1038/s41467-021-27716-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 23
Abstract
SARS-CoV-2 infection can lead to progressive pathology in patients with COVID-19, but information for this disease progression is sparse. Here the authors use multi-omics approach to profile the immune responses of patients, assessing immune repertoire and effects of tocilizumab treatments, to find a dyssynchrony between innate and adaptive immunity in progressive COVID-19.
