PLoS ONE (Jan 2013)

A replication study for association of ITPKC and CASP3 two-locus analysis in IVIG unresponsiveness and coronary artery lesion in Kawasaki disease.

  • Ho-Chang Kuo,
  • Yu-Wen Hsu,
  • Chung-Min Wu,
  • Shawn Hsiang-Yin Chen,
  • Kuo-Sheng Hung,
  • Wei-Pin Chang,
  • Kuender D Yang,
  • Kai-Sheng Hsieh,
  • Wei-Chiao Chen,
  • Yoshihiro Onouchi,
  • Wei-Chiao Chang

DOI
https://doi.org/10.1371/journal.pone.0069685
Journal volume & issue
Vol. 8, no. 7
p. e69685

Abstract

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Single-nucleotide polymorphisms (SNPs) in inositol 1,4,5-trisphosphate 3-kinase C (ITPKC, rs28493229) and caspase-3 (CASP3, rs113420705) are associated with susceptibility to KD in Japanese and Taiwanese populations. This study was conducted to investigate the involvement of these 2 SNPs in the risk for intravenous immunoglobulin (IVIG) resistance and coronary artery lesion (CAL) in Taiwanese population. A total of 340 KD patients were subjected to assess by the identification of 2-locus genes model. A combinatorial association between ITPKC (rs28493229) and CASP3 (rs113420705) was found in CAL formation (P = 0.0227, OR: 3.06). KD patients with high-risk genotype had a trend of overrepresentation in IVIG resistance compared with individual SNPs. Our findings suggest the existence of genetic factors affecting patients' risk for CAL formation and IVIG responsiveness in a Taiwanese population.