HIV-associated gut dysbiosis is independent of sexual practice and correlates with noncommunicable diseases

I. Vujkovic-Cvijin; O. Sortino; E. Verheij; J. Sklar; F. W. Wit; N. A. Kootstra; B. Sellers; J. M. Brenchley; J. Ananworanich; M. Schim van der Loeff; Y. Belkaid; P. Reiss; I. Sereti

doi:10.1038/s41467-020-16222-8

Nature Communications (May 2020)

HIV-associated gut dysbiosis is independent of sexual practice and correlates with noncommunicable diseases

I. Vujkovic-Cvijin,
O. Sortino,
E. Verheij,
J. Sklar,
F. W. Wit,
N. A. Kootstra,
B. Sellers,
J. M. Brenchley,
J. Ananworanich,
M. Schim van der Loeff,
Y. Belkaid,
P. Reiss,
I. Sereti

Affiliations

I. Vujkovic-Cvijin: Metaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH)
O. Sortino: Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, National Cancer Institute
E. Verheij: Amsterdam University Medical Centers, University of Amsterdam, Department of Global Health and Division of Infectious Diseases, Amsterdam Infection and Immunity Institute, Amsterdam Public Health Research Institute, and Amsterdam Institute for Global Health and Development
J. Sklar: Metaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH)
F. W. Wit: Amsterdam University Medical Centers, University of Amsterdam, Department of Global Health and Division of Infectious Diseases, Amsterdam Infection and Immunity Institute, Amsterdam Public Health Research Institute, and Amsterdam Institute for Global Health and Development
N. A. Kootstra: Amsterdam University Medical Centers, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute
B. Sellers: Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation, National Institutes of Health
J. M. Brenchley: Barrier Immunity Section, Laboratory of Viral Diseases, NIAID, NIH
J. Ananworanich: Amsterdam University Medical Centers, University of Amsterdam, Department of Global Health and Division of Infectious Diseases, Amsterdam Infection and Immunity Institute, Amsterdam Public Health Research Institute, and Amsterdam Institute for Global Health and Development
M. Schim van der Loeff: Department of Infectious Diseases, Public Health Service of Amsterdam
Y. Belkaid: Metaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH)
P. Reiss: Amsterdam University Medical Centers, University of Amsterdam, Department of Global Health and Division of Infectious Diseases, Amsterdam Infection and Immunity Institute, Amsterdam Public Health Research Institute, and Amsterdam Institute for Global Health and Development
I. Sereti: HIV Pathogenesis Section, Laboratory of Immunoregulation, NIAID, NIH

DOI: https://doi.org/10.1038/s41467-020-16222-8
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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The role of sexual practice in HIV-associated gut microbiota remains poorly understood. Here, in a cohort of chronically treated HIV-infected people, the authors show microbiome signatures to be independent of sex and sexual practice and that the extent of dysbiosis correlates with nadir CD4, inflammatory markers, and comorbidities.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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