Nature Communications (Dec 2021)
Neuron-specific chromosomal megadomain organization is adaptive to recent retrotransposon expansions
- Sandhya Chandrasekaran,
- Sergio Espeso-Gil,
- Yong-Hwee Eddie Loh,
- Behnam Javidfar,
- Bibi Kassim,
- Yueyan Zhu,
- Yuan Zhang,
- Yuhao Dong,
- Lucy K. Bicks,
- Haixin Li,
- Prashanth Rajarajan,
- Cyril J. Peter,
- Daijing Sun,
- Esperanza Agullo-Pascual,
- Marina Iskhakova,
- Molly Estill,
- Bluma J. Lesch,
- Li Shen,
- Yan Jiang,
- Schahram Akbarian
Affiliations
- Sandhya Chandrasekaran
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Sergio Espeso-Gil
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Yong-Hwee Eddie Loh
- Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Behnam Javidfar
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Bibi Kassim
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Yueyan Zhu
- State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University
- Yuan Zhang
- State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University
- Yuhao Dong
- State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University
- Lucy K. Bicks
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Haixin Li
- Department of Genetics, Yale School of Medicine
- Prashanth Rajarajan
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Cyril J. Peter
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Daijing Sun
- State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University
- Esperanza Agullo-Pascual
- Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Marina Iskhakova
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Molly Estill
- Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Bluma J. Lesch
- Department of Genetics, Yale School of Medicine
- Li Shen
- Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Yan Jiang
- State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University
- Schahram Akbarian
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/s41467-021-26862-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Repeat-rich sequences play a role in 3D genome architecture in higher eukaryotes; however, this remains unexplored in brain cells. Here, the authors show that upregulation of endogenous retroviral (ERV) sequences is linked to changes in the 3D structure in the brain, which is also observed by comparison of mouse strains with recent retrotransposon expansion.
