Cytotoxic Constituents from the Stems of Clausena lansium (Lour.) Skeels

Abstract

Six compounds were isolated from the stems of Clausena lansium (Lour.) Skeels by repeated sillica gel column chromatography. Their chemical structures were elucidated on the basic of physicochemical and spectroscopic data. Among them, 8-geranyloxypsolaren (3) and 2-methoxy-1-(3-methyl-buten-1-yl)-9H-carbazole-3-carbaldehyde (6) were isolated for the first time from this plant. These compounds were screened for cytotoxicity in human cervical cancer (Hela), leukemia (K562), lung cancer (A549), non-small lung carcinoma (H1299) and liver cancer (SMMC-7721). Within the series of cytotoxic tests, compounds 4–6 displayed potent cytotoxic activity against H1299 and SMMC-7721, with the IC50 values of 6.19 to 26.84 μg/mL.

Keywords

• 8-geranyloxypsolaren
• 2-methoxy-1-(3-methyl-buten-1-yl)-9H-carbazole-3-carbaldehyde
• Clausena lansium
• carbazoles
• coumarins
• cytotoxic activity