Nature Communications (Jun 2021)
Coordination of two enhancers drives expression of olfactory trace amine-associated receptors
- Aimei Fei,
- Wanqing Wu,
- Longzhi Tan,
- Cheng Tang,
- Zhengrong Xu,
- Xiaona Huo,
- Hongqiang Bao,
- Yalei Kong,
- Mark Johnson,
- Griffin Hartmann,
- Mustafa Talay,
- Cheng Yang,
- Clemens Riegler,
- Kristian J. Herrera,
- Florian Engert,
- X. Sunney Xie,
- Gilad Barnea,
- Stephen D. Liberles,
- Hui Yang,
- Qian Li
Affiliations
- Aimei Fei
- Center for Brain Science of Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine
- Wanqing Wu
- Center for Brain Science of Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine
- Longzhi Tan
- Department of Chemistry and Chemical Biology, Harvard University
- Cheng Tang
- Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Research Center for Brain Science and Brian-Inspired Intelligence, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Zhengrong Xu
- Center for Brain Science of Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine
- Xiaona Huo
- Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Research Center for Brain Science and Brian-Inspired Intelligence, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Hongqiang Bao
- Center for Brain Science of Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine
- Yalei Kong
- Center for Brain Science of Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine
- Mark Johnson
- Department of Neuroscience, Division of Biology and Medicine, Brown University
- Griffin Hartmann
- Department of Neuroscience, Division of Biology and Medicine, Brown University
- Mustafa Talay
- Department of Neuroscience, Division of Biology and Medicine, Brown University
- Cheng Yang
- Center for Brain Science of Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine
- Clemens Riegler
- Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University
- Kristian J. Herrera
- Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University
- Florian Engert
- Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University
- X. Sunney Xie
- Department of Chemistry and Chemical Biology, Harvard University
- Gilad Barnea
- Department of Neuroscience, Division of Biology and Medicine, Brown University
- Stephen D. Liberles
- Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School
- Hui Yang
- Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Research Center for Brain Science and Brian-Inspired Intelligence, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Qian Li
- Center for Brain Science of Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-23823-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
In our nose, some neuron subpopulations express a family of trace amine associated receptors (TAARs, smelling e.g., rotten fish). Fei et al. identify two conserved enhancers across placental mammals named TAAR enhancer 1 and 2 that coordinately regulate expression of the entire Taar gene repertoire.
