Nature Communications (Jun 2021)
Single cell derived mRNA signals across human kidney tumors
- Matthew D. Young,
- Thomas J. Mitchell,
- Lars Custers,
- Thanasis Margaritis,
- Francisco Morales-Rodriguez,
- Kwasi Kwakwa,
- Eleonora Khabirova,
- Gerda Kildisiute,
- Thomas R. W. Oliver,
- Ronald R. de Krijger,
- Marry M. van den Heuvel-Eibrink,
- Federico Comitani,
- Alice Piapi,
- Eva Bugallo-Blanco,
- Christine Thevanesan,
- Christina Burke,
- Elena Prigmore,
- Kirsty Ambridge,
- Kenny Roberts,
- Felipe A. Vieira Braga,
- Tim H. H. Coorens,
- Ignacio Del Valle,
- Anna Wilbrey-Clark,
- Lira Mamanova,
- Grant D. Stewart,
- Vincent J. Gnanapragasam,
- Dyanne Rampling,
- Neil Sebire,
- Nicholas Coleman,
- Liz Hook,
- Anne Warren,
- Muzlifah Haniffa,
- Marcel Kool,
- Stefan M. Pfister,
- John C. Achermann,
- Xiaoling He,
- Roger A. Barker,
- Adam Shlien,
- Omer A. Bayraktar,
- Sarah A. Teichmann,
- Frank C. Holstege,
- Kerstin B. Meyer,
- Jarno Drost,
- Karin Straathof,
- Sam Behjati
Affiliations
- Matthew D. Young
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Thomas J. Mitchell
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Lars Custers
- Princess Máxima Center for Pediatric Oncology
- Thanasis Margaritis
- Princess Máxima Center for Pediatric Oncology
- Francisco Morales-Rodriguez
- Princess Máxima Center for Pediatric Oncology
- Kwasi Kwakwa
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Eleonora Khabirova
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Gerda Kildisiute
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Thomas R. W. Oliver
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Ronald R. de Krijger
- Princess Máxima Center for Pediatric Oncology
- Marry M. van den Heuvel-Eibrink
- Princess Máxima Center for Pediatric Oncology
- Federico Comitani
- Program in Genetics and Genome Biology, The Hospital for Sick Children
- Alice Piapi
- UCL Great Ormond Street Hospital Institute of Child Health
- Eva Bugallo-Blanco
- UCL Great Ormond Street Hospital Institute of Child Health
- Christine Thevanesan
- UCL Great Ormond Street Hospital Institute of Child Health
- Christina Burke
- UCL Great Ormond Street Hospital Institute of Child Health
- Elena Prigmore
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Kirsty Ambridge
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Kenny Roberts
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Felipe A. Vieira Braga
- Amsterdam UMC, University of Amsterdam
- Tim H. H. Coorens
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Ignacio Del Valle
- UCL Great Ormond Street Hospital Institute of Child Health
- Anna Wilbrey-Clark
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Lira Mamanova
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Grant D. Stewart
- Cambridge University Hospitals NHS Foundation Trust
- Vincent J. Gnanapragasam
- Cambridge University Hospitals NHS Foundation Trust
- Dyanne Rampling
- Great Ormond Street Hospital for Children NHS Foundation Trust
- Neil Sebire
- NIHR Great Ormond Street Hospital BRC and Institute of Child Health
- Nicholas Coleman
- Cambridge University Hospitals NHS Foundation Trust
- Liz Hook
- Cambridge University Hospitals NHS Foundation Trust
- Anne Warren
- Cambridge University Hospitals NHS Foundation Trust
- Muzlifah Haniffa
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Marcel Kool
- Princess Máxima Center for Pediatric Oncology
- Stefan M. Pfister
- Hopp Children´s Cancer Center Heidelberg (KiTZ)
- John C. Achermann
- UCL Great Ormond Street Hospital Institute of Child Health
- Xiaoling He
- MRC-WT Cambridge Stem Cell Institute, University of Cambridge
- Roger A. Barker
- MRC-WT Cambridge Stem Cell Institute, University of Cambridge
- Adam Shlien
- Program in Genetics and Genome Biology, The Hospital for Sick Children
- Omer A. Bayraktar
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Sarah A. Teichmann
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Frank C. Holstege
- Princess Máxima Center for Pediatric Oncology
- Kerstin B. Meyer
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Jarno Drost
- Princess Máxima Center for Pediatric Oncology
- Karin Straathof
- UCL Great Ormond Street Hospital Institute of Child Health
- Sam Behjati
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- DOI
- https://doi.org/10.1038/s41467-021-23949-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
Transcriptomic analysis may provide information about the differentiation state and cell of origin of a cancer. Here, the authors assess mRNA signals in 1300 childhood and adult renal tumors and report a fetal origin of childhood tumors and no dedifferentiation of adult tumors.
