Perampanel in cases of refractory temporal lobe epilepsy – A report of two post-operative and two eligible for temporal lobectomy

Abstract

Background: Temporal Lobectomy (TL) is an accepted surgical procedure for refractory seizures. Aims: To assess the effects of Perampanel (PER) therapy in patients with refractory temporal lobe epilepsy. Methodology: Perampanel therapy was administered in two cases with refractory seizures post temporal lobectomy and in two others with refractory seizures who were eligible for temporal lobectomy. Results: There was significant control in seizures in all the four cases with Perampanel as a single add on to ongoing refractory state.

Keywords

• Temporal Lobectomy
• Epilepsy
• Refractory Seizures
• Mesial Sclerosis
• Perampanel