Application of surface plasmon resonance phenomenon for early detection and determination of the drug concentration for treating the relapses of malignant tumors

Abstract

One of promising directions in oncology is the development of methods for treatment of malignant tumors with account of mechanisms of their genesis and focused on correction of definite pathogenesis components, while being nontoxic for other organs and tissues. Investigated in this work was the possibility to use the phenomenon of surface plasmon resonance (SPR) for analysis of blood inherent to patients with glioma of different degrees of malignancy by studying the level of aggregation of blood cells. For this aim, we ascertained correlation between SPR characteristics and the condition of patient as well as choice of the drug efficient concentration. The works were performed being based on positive results preliminary obtained in experiments with lab rats, which were carried out in cooperation with the State Institution “A.P. Romodanov Institute of Neurosurgery, NAMS of Ukraine”, and V. Lashkaryov Institute of Semiconductor Physics, NAS of Ukraine by using the device “Plasmon”. It has been experimentally shown that, when using the chosen drug by treated patients, the signs of toxical action of verapamil hydrochloride are absent, and the life span is 10 months longer as compared with the group of patients that are not treated with this drug in low concentrations during the postoperative period.

Keywords

• surface plasmon resonance
• aggregation of blood cells
• glioma
• diagnostics
• treatment