OSMR controls glioma stem cell respiration and confers resistance of glioblastoma to ionizing radiation

Ahmad Sharanek; Audrey Burban; Matthew Laaper; Emilie Heckel; Jean-Sebastien Joyal; Vahab D. Soleimani; Arezu Jahani-Asl

doi:10.1038/s41467-020-17885-z

Nature Communications (Aug 2020)

OSMR controls glioma stem cell respiration and confers resistance of glioblastoma to ionizing radiation

Ahmad Sharanek,
Audrey Burban,
Matthew Laaper,
Emilie Heckel,
Jean-Sebastien Joyal,
Vahab D. Soleimani,
Arezu Jahani-Asl

Affiliations

Ahmad Sharanek: Lady Davis Institute for Medical Research, Jewish General Hospital
Audrey Burban: Lady Davis Institute for Medical Research, Jewish General Hospital
Matthew Laaper: Lady Davis Institute for Medical Research, Jewish General Hospital
Emilie Heckel: Departments of Pediatrics, Pharmacology and Ophthalmology, Université de Montréal, CHU Sainte-Justine
Jean-Sebastien Joyal: Departments of Pediatrics, Pharmacology and Ophthalmology, Université de Montréal, CHU Sainte-Justine
Vahab D. Soleimani: Lady Davis Institute for Medical Research, Jewish General Hospital
Arezu Jahani-Asl: Lady Davis Institute for Medical Research, Jewish General Hospital

DOI: https://doi.org/10.1038/s41467-020-17885-z
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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The suppression of the receptor for oncostatin M (OSMR) can prevent glioblastoma cell growth. Here, the authors demonstrate a role for OSMR in modulating glioma stem cell respiration and its impact on resistance to ionizing radiation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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