Nature Communications (Sep 2016)
Broad activation of latent HIV-1 in vivo
- Kirston Barton,
- Bonnie Hiener,
- Anni Winckelmann,
- Thomas Aagaard Rasmussen,
- Wei Shao,
- Karen Byth,
- Robert Lanfear,
- Ajantha Solomon,
- James McMahon,
- Sean Harrington,
- Maria Buzon,
- Mathias Lichterfeld,
- Paul W. Denton,
- Rikke Olesen,
- Lars Østergaard,
- Martin Tolstrup,
- Sharon R. Lewin,
- Ole Schmeltz Søgaard,
- Sarah Palmer
Affiliations
- Kirston Barton
- Centre for Virus Research, The Westmead Institute for Medical Research, The University of Sydney
- Bonnie Hiener
- Centre for Virus Research, The Westmead Institute for Medical Research, The University of Sydney
- Anni Winckelmann
- Centre for Virus Research, The Westmead Institute for Medical Research, The University of Sydney
- Thomas Aagaard Rasmussen
- Department of Infectious Diseases, Aarhus University Hospital
- Wei Shao
- Advanced Biomedical Computing Center, Leidos Biomedical Research Inc.
- Karen Byth
- NWSLHD Research and Education Network
- Robert Lanfear
- Department of Biological Sciences, Macquarie University
- Ajantha Solomon
- The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and Royal Melbourne Hospital
- James McMahon
- Department of Infectious Diseases, Alfred Hospital and Monash University
- Sean Harrington
- Ragon Institute of MGH, MIT, Harvard
- Maria Buzon
- Ragon Institute of MGH, MIT, Harvard
- Mathias Lichterfeld
- Ragon Institute of MGH, MIT, Harvard
- Paul W. Denton
- Department of Infectious Diseases, Aarhus University Hospital
- Rikke Olesen
- Department of Infectious Diseases, Aarhus University Hospital
- Lars Østergaard
- Department of Infectious Diseases, Aarhus University Hospital
- Martin Tolstrup
- Department of Infectious Diseases, Aarhus University Hospital
- Sharon R. Lewin
- The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and Royal Melbourne Hospital
- Ole Schmeltz Søgaard
- Department of Infectious Diseases, Aarhus University Hospital
- Sarah Palmer
- Centre for Virus Research, The Westmead Institute for Medical Research, The University of Sydney
- DOI
- https://doi.org/10.1038/ncomms12731
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 8
Abstract
Treatment of HIV-1 infected patients with latency-reversing agents (LRA) induces transcription of proviruses in CD4 T cells. Using single-genome sequencing, the authors show that the LRA-induced CD4 T cell-associated HIV RNA is genetically diverse and contains a high proportion of defective RNA.
