Annals of Clinical and Translational Neurology (Sep 2023)
HLA in isolated REM sleep behavior disorder and Lewy body dementia
- Eric Yu,
- Lynne Krohn,
- Jennifer A. Ruskey,
- Farnaz Asayesh,
- Dan Spiegelman,
- Zalak Shah,
- Ruth Chia,
- Isabelle Arnulf,
- Michele T. M. Hu,
- Jacques Y. Montplaisir,
- Jean‐François Gagnon,
- Alex Desautels,
- Yves Dauvilliers,
- Gian Luigi Gigli,
- Mariarosaria Valente,
- Francesco Janes,
- Andrea Bernardini,
- Birgit Högl,
- Ambra Stefani,
- Abubaker Ibrahim,
- Anna Heidbreder,
- Karel Sonka,
- Petr Dusek,
- David Kemlink,
- Wolfgang Oertel,
- Annette Janzen,
- Giuseppe Plazzi,
- Elena Antelmi,
- Michela Figorilli,
- Monica Puligheddu,
- Brit Mollenhauer,
- Claudia Trenkwalder,
- Friederike Sixel‐Döring,
- Valérie Cochen De Cock,
- Luigi Ferini‐Strambi,
- Femke Dijkstra,
- Mineke Viaene,
- Beatriz Abril,
- Bradley F. Boeve,
- Guy A. Rouleau,
- Ronald B. Postuma,
- The International LBD Genomics Consortium,
- Sonja W. Scholz,
- Ziv Gan‐Or
Affiliations
- Eric Yu
- Department of Human Genetics McGill University Montréal Québec Canada
- Lynne Krohn
- Department of Human Genetics McGill University Montréal Québec Canada
- Jennifer A. Ruskey
- The Neuro (Montréal Neurological Institute‐Hospital) McGill University Montréal Québec Canada
- Farnaz Asayesh
- The Neuro (Montréal Neurological Institute‐Hospital) McGill University Montréal Québec Canada
- Dan Spiegelman
- The Neuro (Montréal Neurological Institute‐Hospital) McGill University Montréal Québec Canada
- Zalak Shah
- Neurodegenerative Diseases Research Unit National Institute of Neurological Disorders and Stroke Bethesda Maryland USA
- Ruth Chia
- Neuromuscular Diseases Research Section National Institute on Aging Bethesda Maryland USA
- Isabelle Arnulf
- Sleep Disorders Unit, Pitié Salpêtrière Hospital Paris Brain Institute and Sorbonne University Paris France
- Michele T. M. Hu
- Oxford Parkinson's Disease Centre (OPDC) University of Oxford Oxford UK
- Jacques Y. Montplaisir
- Center for Advanced Research in Sleep Medicine Centre Intégré Universitaire de Santé et de Services Sociaux du Nord‐de‐l'Île‐de‐Montréal – Hôpital du Sacré‐Coeur de Montréal Montréal Québec Canada
- Jean‐François Gagnon
- Center for Advanced Research in Sleep Medicine Centre Intégré Universitaire de Santé et de Services Sociaux du Nord‐de‐l'Île‐de‐Montréal – Hôpital du Sacré‐Coeur de Montréal Montréal Québec Canada
- Alex Desautels
- Center for Advanced Research in Sleep Medicine Centre Intégré Universitaire de Santé et de Services Sociaux du Nord‐de‐l'Île‐de‐Montréal – Hôpital du Sacré‐Coeur de Montréal Montréal Québec Canada
- Yves Dauvilliers
- National Reference Center for Narcolepsy, Sleep Unit, Department of Neurology, Gui‐de‐Chauliac Hospital, CHU Montpellier University of Montpellier, Inserm U1061 Montpellier France
- Gian Luigi Gigli
- Clinical Neurology Unit, Department of Neurosciences University Hospital of Udine Udine Italy
- Mariarosaria Valente
- Clinical Neurology Unit, Department of Neurosciences University Hospital of Udine Udine Italy
- Francesco Janes
- Clinical Neurology Unit, Department of Neurosciences University Hospital of Udine Udine Italy
- Andrea Bernardini
- Clinical Neurology Unit, Department of Neurosciences University Hospital of Udine Udine Italy
- Birgit Högl
- Sleep Disorders Clinic, Department of Neurology Medical University of Innsbruck Innsbruck Austria
- Ambra Stefani
- Sleep Disorders Clinic, Department of Neurology Medical University of Innsbruck Innsbruck Austria
- Abubaker Ibrahim
- Sleep Disorders Clinic, Department of Neurology Medical University of Innsbruck Innsbruck Austria
- Anna Heidbreder
- Department for Sleep Medicine and Neuromuscular disease University Hospital Muenster Muenster Germany
- Karel Sonka
- Department of Neurology and Centre of Clinical Neuroscience Charles University, First Faculty of Medicine and General University Hospital Prague Czech Republic
- Petr Dusek
- Department of Neurology and Centre of Clinical Neuroscience Charles University, First Faculty of Medicine and General University Hospital Prague Czech Republic
- David Kemlink
- Department of Neurology and Centre of Clinical Neuroscience Charles University, First Faculty of Medicine and General University Hospital Prague Czech Republic
- Wolfgang Oertel
- Department of Neurology Philipps University Marburg Germany
- Annette Janzen
- Department of Neurology Philipps University Marburg Germany
- Giuseppe Plazzi
- Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio‐Emilia Modena Italy
- Elena Antelmi
- Neurology Unit, Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences University of Verona Verona Italy
- Michela Figorilli
- Department of Medical Sciences and Public Health, Sleep Disorder Research Center University of Cagliari Cagliari Italy
- Monica Puligheddu
- Department of Medical Sciences and Public Health, Sleep Disorder Research Center University of Cagliari Cagliari Italy
- Brit Mollenhauer
- Paracelsus‐Elena‐Klinik Kassel Germany
- Claudia Trenkwalder
- Paracelsus‐Elena‐Klinik Kassel Germany
- Friederike Sixel‐Döring
- Department of Neurology Philipps University Marburg Germany
- Valérie Cochen De Cock
- Sleep and Neurology Unit Beau Soleil Clinic Montpellier France
- Luigi Ferini‐Strambi
- Department of Neurological Sciences Università Vita‐Salute San Raffaele Milan Italy
- Femke Dijkstra
- Laboratory for Sleep Disorders St. Dimpna Regional Hospital Geel Belgium
- Mineke Viaene
- Laboratory for Sleep Disorders St. Dimpna Regional Hospital Geel Belgium
- Beatriz Abril
- Sleep disorder Unit Carémeau Hospital, University Hospital of Nîmes Nîmes France
- Bradley F. Boeve
- Department of Neurology Mayo Clinic Rochester Minnesota USA
- Guy A. Rouleau
- Department of Human Genetics McGill University Montréal Québec Canada
- Ronald B. Postuma
- The Neuro (Montréal Neurological Institute‐Hospital) McGill University Montréal Québec Canada
- The International LBD Genomics Consortium
- Sonja W. Scholz
- Neurodegenerative Diseases Research Unit National Institute of Neurological Disorders and Stroke Bethesda Maryland USA
- Ziv Gan‐Or
- Department of Human Genetics McGill University Montréal Québec Canada
- DOI
- https://doi.org/10.1002/acn3.51841
- Journal volume & issue
-
Vol. 10,
no. 9
pp. 1682 – 1687
Abstract
Abstract Synucleinopathies‐related disorders such as Lewy body dementia (LBD) and isolated/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen (HLA) locus plays a role in iRBD and LBD. In iRBD, HLA‐DRB1*11:01 was the only allele passing FDR correction (OR = 1.57, 95% CI = 1.27–1.93, p = 2.70e‐05). We also discovered associations between iRBD and HLA‐DRB1 70D (OR = 1.26, 95%CI = 1.12–1.41, p = 8.76e‐05), 70Q (OR = 0.81, 95%CI = 0.72–0.91, p = 3.65e‐04) and 71R (OR = 1.21, 95%CI = 1.08–1.35, p = 1.35e‐03). Position 71 (pomnibus = 0.00102) and 70 (pomnibus = 0.00125) were associated with iRBD. Our results suggest that the HLA locus may have different roles across synucleinopathies.
