An Efficient Method for the Preparation of N-Formamides using Propylphosphonic Anhydride (T3P®)

Abstract

Abstract The synthesis of N-formamides from aromatic amines and formic acid using propylphosphonic anhydride (T3P®) as a green coupling reagent is described. By using this method, aryl, heteroaryl and fluorinated aryl-containing formamides were synthesized in high yield and purity. The significant features of this method include easy work up, high purity and reduced toxicity of the reaction.

Keywords

• n-formylation
• t3p
• formic acid
• aromatic amine
• formamide