P791: COMMON VARIANTS IN COMPLEMENT PROTEINS, C3 AND CR1, ENHANCE COMPLEMENT ATTACK ON PNH ERYTHROCYTES AND INCREASE RISK FOR EXTRAVASCULAR HAEMOLYSIS

• A. J. Baral,
• C. Mckinley,
• R. Fellows,
• T. Hallam,
• T. Cox,
• D. Payne,
• S. Richards,
• A. Pike,
• R. Kelly,
• M. Griffin,
• P. Hillmen,
• K. Marchbank,
• D. Kavanagh,
• D. Newton,
• C. Harris

Affiliations

A. J. Baral

1 Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne

C. Mckinley

2 Division of Haematology and Immunology, Leeds Institute of Medical Research, University of Leeds

R. Fellows

1 Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne

T. Hallam

1 Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne

T. Cox

1 Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne

D. Payne

3 Haematological Malignancy Diagnostic Service, St. James’s University Hospital

S. Richards

2 Division of Haematology and Immunology, Leeds Institute of Medical Research, University of Leeds

A. Pike

4 Department of Haematology, St James University Hospital, Leeds

R. Kelly

4 Department of Haematology, St James University Hospital, Leeds

M. Griffin

4 Department of Haematology, St James University Hospital, Leeds

P. Hillmen

2 Division of Haematology and Immunology, Leeds Institute of Medical Research, University of Leeds

K. Marchbank

1 Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne

D. Kavanagh

5 Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne

D. Newton

6 Division of Haematology and Immunology, Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom

C. Harris

1 Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne