Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations

Benedetta Mariotti; Federico Meconi; Raffaele Palmieri; Eleonora De Bellis; Serena Lavorgna; Tiziana Ottone; Vincenza Martini; Francesco Lo-Coco; Laura Cicconi

doi:10.1155/2019/6707506

Case Reports in Hematology (Jan 2019)

Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations

Benedetta Mariotti,
Federico Meconi,
Raffaele Palmieri,
Eleonora De Bellis,
Serena Lavorgna,
Tiziana Ottone,
Vincenza Martini,
Francesco Lo-Coco,
Laura Cicconi

Affiliations

Benedetta Mariotti: Department of Biomedicine and Prevention, University Tor Vergata, Rome, Italy
Federico Meconi: Department of Biomedicine and Prevention, University Tor Vergata, Rome, Italy
Raffaele Palmieri: Department of Biomedicine and Prevention, University Tor Vergata, Rome, Italy
Eleonora De Bellis: Department of Biomedicine and Prevention, University Tor Vergata, Rome, Italy
Serena Lavorgna: Department of Biomedicine and Prevention, University Tor Vergata, Rome, Italy
Tiziana Ottone: Department of Biomedicine and Prevention, University Tor Vergata, Rome, Italy
Vincenza Martini: UOC Ematologia, Ospedale “Fabrizio Spaziani”, Frosinone, Italy
Francesco Lo-Coco: Department of Biomedicine and Prevention, University Tor Vergata, Rome, Italy
Laura Cicconi: Department of Biomedicine and Prevention, University Tor Vergata, Rome, Italy

DOI: https://doi.org/10.1155/2019/6707506
Journal volume & issue: Vol. 2019

Abstract

Read online

We present a case report of a patient with acute myeloid leukemia (AML) characterized by the simultaneous presence of nucleophosmin 1 (NPM1) mutation and the breakpoint cluster region-Abelson (BCR-ABL) fusion oncogene. Our findings emphasize the importance of routinely including BCR-ABL in the diagnostic workup of AML in order to offer to the patients the most appropriate risk category and treatment options.

Published in Case Reports in Hematology

ISSN: 2090-6560 (Print); 2090-6579 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs
Website: https://www.hindawi.com/journals/crihem/

About the journal