Filaggrin-deficient rats generated using zinc-finger nucleases spontaneously exhibit dry scaly skin

• Chisa Nakashima,
• Hiromi Doi,
• Saeko Nakajima,
• Tomoji Mashimo,
• Toru Oga,
• Akemi Ishida-Yamamoto,
• Tetsuya Honda,
• Yoshihiro Ishida,
• Atsushi Otsuka,
• Kenji Kabashima

Affiliations

Chisa Nakashima

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Dermatology, Faculty of Medicine, Kindai University Hospital, Osaka, Japan

Hiromi Doi

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan

Saeko Nakajima

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Drug Discovery for Inflammatory Skin Diseases, Kyoto University Graduate School of Medicine, Kyoto, Japan

Tomoji Mashimo

Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Toru Oga

Department of Respiratory Care and Sleep Control Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Akemi Ishida-Yamamoto

Department of Dermatology, Asahikawa Medical University, Hokkaido, Japan

Tetsuya Honda

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan

Yoshihiro Ishida

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan

Atsushi Otsuka

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Dermatology, Faculty of Medicine, Kindai University Hospital, Osaka, Japan; Translational Research Department for Skin and Brain Diseases, Kyoto University Graduate School of Medicine, Kyoto, Japan; Corresponding author. Department of Dermatology, Kyoto University Graduate School of Medicine 54 Shogoin-Kawahara, Sakyo-ku, Kyoto 606-8507, Japan.

Kenji Kabashima

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Skin Research Institute of Singapore (SRIS), Agency for Science, Technology and Research (A∗STAR), Biopolis, Singapore; Corresponding author. Department of Dermatology, Kyoto University Graduate School of Medicine 54 Shogoin-Kawahara, Sakyo-ku, Kyoto 606-8507, Japan.