Non-invasive measurement of rat auditory evoked fields using an optically pumped atomic magnetometer: Effects of task manipulation

Yi Ruan; Zhao Xiang; Guanzhong Lu; Yuhai Chen; Yufei Liu; Fan Liu; Jiahao Wang; Ying Zhang; Jia Yao; Yu Liu; Qiang Lin

Heliyon (Jun 2024)

Non-invasive measurement of rat auditory evoked fields using an optically pumped atomic magnetometer: Effects of task manipulation

Yi Ruan,
Zhao Xiang,
Guanzhong Lu,
Yuhai Chen,
Yufei Liu,
Fan Liu,
Jiahao Wang,
Ying Zhang,
Jia Yao,
Yu Liu,
Qiang Lin

Affiliations

Yi Ruan: Zhejiang Provincial Key Laboratory and Collaborative Innovation Center for Quantum Precision Measurement, College of Science, Zhejiang University of Technology, Hangzhou, 310023, China; Corresponding authors. College of Science, Zhejiang University of Technology, No. 288, Liuhe Road, Hangzhou, Zhejiang Province, China.
Zhao Xiang: Zhejiang Provincial Key Laboratory and Collaborative Innovation Center for Quantum Precision Measurement, College of Science, Zhejiang University of Technology, Hangzhou, 310023, China
Guanzhong Lu: Zhejiang Provincial Key Laboratory and Collaborative Innovation Center for Quantum Precision Measurement, College of Science, Zhejiang University of Technology, Hangzhou, 310023, China
Yuhai Chen: Zhejiang Provincial Key Laboratory and Collaborative Innovation Center for Quantum Precision Measurement, College of Science, Zhejiang University of Technology, Hangzhou, 310023, China
Yufei Liu: Zhejiang Provincial Key Laboratory and Collaborative Innovation Center for Quantum Precision Measurement, College of Science, Zhejiang University of Technology, Hangzhou, 310023, China
Fan Liu: Zhejiang Provincial Key Laboratory and Collaborative Innovation Center for Quantum Precision Measurement, College of Science, Zhejiang University of Technology, Hangzhou, 310023, China
Jiahao Wang: Zhejiang Provincial Key Laboratory and Collaborative Innovation Center for Quantum Precision Measurement, College of Science, Zhejiang University of Technology, Hangzhou, 310023, China
Ying Zhang: Department of Endocrinology and Metabolism, Shaoxing Second Hospital, Shaoxing, 312000, China
Jia Yao: Department of Breast Surgery, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 311121, China
Yu Liu: Department of Breast Surgery, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 311121, China
Qiang Lin: Zhejiang Provincial Key Laboratory and Collaborative Innovation Center for Quantum Precision Measurement, College of Science, Zhejiang University of Technology, Hangzhou, 310023, China; Corresponding author.

Journal volume & issue: Vol. 10, no. 11
p. e31740

Abstract

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Optically pumped magnetometers (OPMs) have become a favorable tool for magnetoencephalography (MEG) measurement, offering a non-invasive method of measurement. OPMs do not require cryogenic environments, sensors can be more closely aligned with the brain. We employed a passive single-stimulus paradigm in conjunction with OPMs with a sensitivity of 20 fT/ Hz to investigate the auditory response of rats to inter-stimulus interval (ISI) and frequencies, recording the rat auditory event-related magnetic fields (ERMFs). Our findings include: (1) Auditory evoked fields can be detected non-invasively by OPMs; (2) The amplitude of the rat auditory ERMFs varies with changes in ISI, with more pronounced amplitude changes observed after 5 s; (3) When the sound stimulus frequency is altered at the same ISI, the amplitude of the rats ERMFs changes with frequency, indicating significant differences in attention. Our method offers a valuable tool for the clinical application of a single stimulus paradigm and opens up a new avenue for research on the brain magnetic field detections.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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