Molecules (Jan 2021)

Continuous-Flow Synthesis of Thioureas, Enabled by Aqueous Polysulfide Solution

  • András Gy. Németh,
  • Renáta Szabó,
  • György Orsy,
  • István M. Mándity,
  • György M. Keserű,
  • Péter Ábrányi-Balogh

DOI
https://doi.org/10.3390/molecules26020303
Journal volume & issue
Vol. 26, no. 2
p. 303

Abstract

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We have developed the continuous-flow synthesis of thioureas in a multicomponent reaction starting from isocyanides, amidines, or amines and sulfur. The aqueous polysulfide solution enabled the application of sulfur under homogeneous and mild conditions. The crystallized products were isolated by simple filtration after the removal of the co-solvent, and the sulfur retained in the mother liquid. Presenting a wide range of thioureas synthesized by this procedure confirms the utility of the convenient continuous-flow application of sulfur.

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