Nature Communications (Jan 2018)

Punctuated evolution of canonical genomic aberrations in uveal melanoma

  • Matthew G. Field,
  • Michael A. Durante,
  • Hima Anbunathan,
  • Louis Z. Cai,
  • Christina L. Decatur,
  • Anne M. Bowcock,
  • Stefan Kurtenbach,
  • J. William Harbour

DOI
https://doi.org/10.1038/s41467-017-02428-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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Uveal melanoma (UM), the most common primary eye cancer, is strongly linked to mutations in the tumor suppressor BAP1. Here, the authors analyze 151 primary UM samples to find that BAP1 and other canonical genomic aberrations arise in an early punctuated burst followed by neutral tumor evolution.