Application of coating technology to chronotherapeutic drug delivery systems: Recent publications and patents

Abstract

In general, extended release systems have the ability to maintain the drug concentration with in therapeutic range for prolonged period of time, but this may not be the primary requisite for circadian rhythm diseases like asthma, hypertension and rheumatoid arthritis, etc. They require prompt release of drug as per the disease condition, which can be achieved by programmed lag time. Chronotherapeutic drug delivery systems (CDDS) can be achieved by several methods, coating is one amongst them. Though the coating process is complex in terms of methodology, solubility issues and difficulty in achieving the uniform coating, many researchers were successfully employed in development of CDDS. A scientific prospection was made from 2010 to 2020 using PubMed database. Apart from exploration of publication data, we attempt to brief about classification of patents and concordance. The scrutiny also highlights the patents filed on chronotherapeutic systems, focusing particularly on coating technologies. The review is concluded the successful application of coating technology to develop CDDS, as evident from vast number of publications and patents filed.

Keywords

• Chronotherapeutics
• Coating
• Scientific prospection
• Patents