Production and Utilization of SPIONs for In-vitro Drug Release and X-ray Imaging

Antony V. Samrot; Saipriya C.; Durga Sruthi P.; A. Jenifer Selvarani; Raji P.; Prakash P.; Paulraj Ponnaiah; Thirumurugan R.; Sajeesh Pattammadath; Sajna Keeyari Purayil; Pazhayakath Thevarkattil Mohamed Javad; Iyappan P.

doi:10.22207/JPAM.14.2.27

Journal of Pure and Applied Microbiology (Jun 2020)

Production and Utilization of SPIONs for In-vitro Drug Release and X-ray Imaging

Antony V. Samrot,
Saipriya C.,
Durga Sruthi P.,
A. Jenifer Selvarani,
Raji P.,
Prakash P.,
Paulraj Ponnaiah,
Thirumurugan R.,
Sajeesh Pattammadath,
Sajna Keeyari Purayil,
Pazhayakath Thevarkattil Mohamed Javad,
Iyappan P.

Affiliations

Antony V. Samrot: ORCiD; School of Biosciences, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom, Selangor - 42610, Malaysia.
Saipriya C.: Department of Biotechnology, Sathyabama Institute of Science and Technology, Jeppiar Nagar, Chennai - 600 119, Tamil Nadu, India.
Durga Sruthi P.: Department of Biotechnology, Sathyabama Institute of Science and Technology, Jeppiar Nagar, Chennai - 600 119, Tamil Nadu, India.
A. Jenifer Selvarani: Department of Biotechnology, Sathyabama Institute of Science and Technology, Jeppiar Nagar, Chennai - 600 119, Tamil Nadu, India.
Raji P.: Department of Biotechnology, Sathyabama Institute of Science and Technology, Jeppiar Nagar, Chennai - 600 119, Tamil Nadu, India.
Prakash P.: Department of Biotechnology, Sathyabama Institute of Science and Technology, Jeppiar Nagar, Chennai - 600 119, Tamil Nadu, India.
Paulraj Ponnaiah: School of Biosciences, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom, Selangor - 42610, Malaysia.
Thirumurugan R.: Department of Transfusion Medicine, JIPMER, Puducherry - 605 006, India.
Sajeesh Pattammadath: School of Biosciences, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom, Selangor - 42610, Malaysia.
Sajna Keeyari Purayil: School of Biosciences, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom, Selangor - 42610, Malaysia.
Pazhayakath Thevarkattil Mohamed Javad: School of Biosciences, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom, Selangor - 42610, Malaysia.
Iyappan P.: School of Biosciences, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom, Selangor - 42610, Malaysia.

DOI: https://doi.org/10.22207/JPAM.14.2.27
Journal volume & issue: Vol. 14, no. 2
pp. 1317 – 1322

Abstract

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In this study, SPIONs were produced in the presence of cobalt as catalyst. SPIONs formed by this chemical co-precipitation were size around 20 nm. After producing the SPIONs, it was subjected for functionalization with oleic acid and loaded with drug - itraconazole (a drug possess antifungal and antibacterial activity) and encapsulated with polyhydroxybutyrate (PHB). The produced core-shell SPIONS was used for antimicrobial study against two bacteria namely - Pseudomonas aeruginosa and Brevibacillus brevis and a fungi - Candida albicans. It was found to be effectively releasing drug for more than 3 hours. The SPIONs alone was acting good as contrasting agent and used for enhancing X-ray imaging.

Published in Journal of Pure and Applied Microbiology

ISSN: 0973-7510 (Print); 2581-690X (Online)
Publisher: Journal of Pure and Applied Microbiology
Country of publisher: India
LCC subjects: Science: Microbiology
Website: https://www.microbiologyjournal.org/

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