Allogeneic Mesenchymal Stromal Cell Injection to Alleviate Ischemic Heart Failure Following Arterial Switch Operation

Filippo Rapetto, MD; Demetris Taliotis, MD; Qiang Chen, MD; Iakovos Ttofi, MD; Dominga Iacobazzi, PhD; Paolo Madeddu, PhD; Serban C. Stoica, MD; Ben Weil, EngD; Mark W. Lowdell, PhD; Massimo Caputo, MD

JACC: Case Reports (May 2021)

Allogeneic Mesenchymal Stromal Cell Injection to Alleviate Ischemic Heart Failure Following Arterial Switch Operation

Filippo Rapetto, MD,
Demetris Taliotis, MD,
Qiang Chen, MD,
Iakovos Ttofi, MD,
Dominga Iacobazzi, PhD,
Paolo Madeddu, PhD,
Serban C. Stoica, MD,
Ben Weil, EngD,
Mark W. Lowdell, PhD,
Massimo Caputo, MD

Affiliations

Filippo Rapetto, MD: Department of Cardiac Surgery, Bristol Heart Institute and Bristol Royal Hospital for Children, Bristol, United Kingdom; Translational Health Sciences, University of Bristol, Bristol, United Kingdom; Address for correspondence: Dr. Filippo Rapetto, Bristol Heart Institute, Upper Maudlin Street, Bristol BS2 8HW, United Kingdom.
Demetris Taliotis, MD: Department of Cardiology, Bristol Heart Institute and Bristol Royal Hospital for Children, Bristol, United Kingdom
Qiang Chen, MD: Department of Cardiac Surgery, Bristol Heart Institute and Bristol Royal Hospital for Children, Bristol, United Kingdom
Iakovos Ttofi, MD: Department of Cardiac Surgery, Bristol Heart Institute and Bristol Royal Hospital for Children, Bristol, United Kingdom
Dominga Iacobazzi, PhD: Translational Health Sciences, University of Bristol, Bristol, United Kingdom
Paolo Madeddu, PhD: Translational Health Sciences, University of Bristol, Bristol, United Kingdom
Serban C. Stoica, MD: Department of Cardiac Surgery, Bristol Heart Institute and Bristol Royal Hospital for Children, Bristol, United Kingdom
Ben Weil, EngD: Centre for Cell, Gene & Tissue Therapeutics, Royal Free London NHS Foundation Trust, London, United Kingdom
Mark W. Lowdell, PhD: Centre for Cell, Gene & Tissue Therapeutics, Royal Free London NHS Foundation Trust, London, United Kingdom
Massimo Caputo, MD: Department of Cardiac Surgery, Bristol Heart Institute and Bristol Royal Hospital for Children, Bristol, United Kingdom; Translational Health Sciences, University of Bristol, Bristol, United Kingdom

Journal volume & issue: Vol. 3, no. 5
pp. 724 – 727

Abstract

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Cell therapy is a promising tool to prevent and treat heart failure in congenital heart disease. We report the first case of intramyocardial injection of allogeneic mesenchymal stromal cells as rescue therapy in a neonate with ischemic heart failure following arterial switch procedure for isolated transposition of the great arteries. (Level of Difficulty: Advanced.)

Published in JACC: Case Reports

ISSN: 2666-0849 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-case-reports

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Abstract

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