Penile cancer with positive nodes: A case of HPV p16-positivity and its significance, implication of data from head and neck cancer

Cam Nguyen; Stephen Leslie; John Gross; Nicholas Dietz; Subodh M. Lele; Gopi Sirineni

Urology Case Reports (Nov 2019)

Penile cancer with positive nodes: A case of HPV p16-positivity and its significance, implication of data from head and neck cancer

Cam Nguyen,
Stephen Leslie,
John Gross,
Nicholas Dietz,
Subodh M. Lele,
Gopi Sirineni

Affiliations

Cam Nguyen: Division of Radiation Oncology, Creighton University Medical Center, Omaha, NE, USA; Corresponding author. Division of Radiation Oncology, Creighton University Medical Center, 7500 Mercy Rd, Omaha, NE, 68124, USA.
Stephen Leslie: Department of Urology, Creighton University School of Medicine, Omaha, NE, USA
John Gross: Department of Pathology, Creighton University Medical Center, Omaha, NE, USA
Nicholas Dietz: Department of Pathology, Creighton University Medical Center, Omaha, NE, USA
Subodh M. Lele: Department of Pathology, University of Nebraska Medical Center, Omaha, NE, USA
Gopi Sirineni: Department of Radiology, Creighton University Medical Center, Omaha, NE, USA

Journal volume & issue: Vol. 27

Abstract

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Penile cancer is normally discovered in an early stage due to its visibility to the patient. This case report demonstrates a morbidly obese patient with a locally advanced penile cancer hidden by fatty tissue. Biopsy showed P16-positive tumor cells, which responded to concurrent chemo-radiotherapy with no evidence of disease at 24 months of follow-up. We also review the significance of p16-positive cell biology. Keywords: Penile cancer, Anal cancer, Chemotherapy, Radiotherapy, HPV, p16

Published in Urology Case Reports

ISSN: 2214-4420 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the genitourinary system. Urology
Website: http://www.urologycasereports.com/

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