THE DIAGNOSTIC INFORMATIVENESS OF THE ANALYSIS OF ORAL FLUID INDICATORS FOR THE ASSESSMENT OF METABOLISM IN PATIENTS WITH OBESITY

Abstract

Aim - to study the informativeness of the analysis of oral fluid parameters to assess the state of metabolism in patients with obesity. Materials and methods. The article studied the indicators of oral fluid and blood, wich characterized the metabolism, among 58 patients with II type of obesity (36 women and 22 men, mean age 39.5±6.2 years). Results. It was found, that the most pronounced changes in biochemical parameters of blood during obesity are observed from the side of lipid metabolism. From 34.62% of patients increased content of cholesterol in blood, 22.22% of patients, triglycerides. Glucose concentration exceeded the reference value in 25.93% of patients. The greatest changes in indicators of the oral fluid was found in triglycerides - they have a high level of 66.67% of the patients. The comparison of the indicators in the blood and oral fluid was revealed, that the increase in triglycerides in the oral fluid is accompanied by a similar trend in the blood in 22.22% of cases. Among those with a high concentration of glucose in oral fluid at 50.0% of cases revealed hyperglycemia. The evaluation of enzyme activity, despite the rather pronounced shifts in the blood, we found, that there was no significant increase in the oral fluid activity of the transaminases studied. Conclusion. Oral fluid is a useful biological material for the assessment of metabolism in patients with obesity. The most informative indicators of oral fluid to assess the state of metabolism in patients with obesity were triglycerines and glucose. The results of the study are necessary for the development of rapid systems for the diagnosis and monitoring of the effectiveness of treatment of obesity by a doctor and a patient.

Keywords

• biochemistry
• food hygiene
• obesity
• metabolism
• oral fluid
• blood