Zinc Finger Proteins in Neuro-Related Diseases Progression

Siyuan Bu; Yihan Lv; Yusheng Liu; Sen Qiao; Hongmei Wang

doi:10.3389/fnins.2021.760567

Frontiers in Neuroscience (Nov 2021)

Zinc Finger Proteins in Neuro-Related Diseases Progression

Siyuan Bu,
Yihan Lv,
Yusheng Liu,
Sen Qiao,
Hongmei Wang

Affiliations

Siyuan Bu: Department of Pharmacology, School of Medicine, Southeast University, Nanjing, China
Yihan Lv: Department of Pharmacology, School of Medicine, Southeast University, Nanjing, China
Yusheng Liu: Department of Pharmacology, School of Medicine, Southeast University, Nanjing, China
Sen Qiao: Department of Pharmacology, Center for Molecular Signaling (PZMS), School of Medicine, Saarland University, Homburg, Germany
Hongmei Wang: Department of Pharmacology, School of Medicine, Southeast University, Nanjing, China

DOI: https://doi.org/10.3389/fnins.2021.760567
Journal volume & issue: Vol. 15

Abstract

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Zinc finger proteins (ZNF) are among the most abundant proteins in eukaryotic genomes. It contains several zinc finger domains that can selectively bind to certain DNA or RNA and associate with proteins, therefore, ZNF can regulate gene expression at the transcriptional and translational levels. In terms of neurological diseases, numerous studies have shown that many ZNF are associated with neurological diseases. The purpose of this review is to summarize the types and roles of ZNF in neuropsychiatric disorders. We will describe the structure and classification of ZNF, then focus on the pathophysiological role of ZNF in neuro-related diseases and summarize the mechanism of action of ZNF in neuro-related diseases.

Published in Frontiers in Neuroscience

ISSN: 1662-4548 (Print); 1662-453X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/neuroscience

About the journal

Abstract

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