Serotonin modulates asymmetric learning from reward and punishment in healthy human volunteers

Jochen Michely; Eran Eldar; Alon Erdman; Ingrid M. Martin; Raymond J. Dolan

doi:10.1038/s42003-022-03690-5

Communications Biology (Aug 2022)

Serotonin modulates asymmetric learning from reward and punishment in healthy human volunteers

Jochen Michely,
Eran Eldar,
Alon Erdman,
Ingrid M. Martin,
Raymond J. Dolan

Affiliations

Jochen Michely: Department of Psychiatry and Neurosciences, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin
Eran Eldar: Psychology and Cognitive Sciences Departments, Hebrew University of Jerusalem
Alon Erdman: Psychology and Cognitive Sciences Departments, Hebrew University of Jerusalem
Ingrid M. Martin: Wellcome Centre for Human Neuroimaging, University College London
Raymond J. Dolan: Max Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London

DOI: https://doi.org/10.1038/s42003-022-03690-5
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 9

Abstract

Read online

Two factors can drive learning: punishment of failures and reward of successes. Serotonin induces a valence-dependent learning asymmetry, as revealed by prolonged administering of SSRIs to healthy participants in a gambling task.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal