Distributed genetic architecture across the hippocampal formation implies common neuropathology across brain disorders

Shahram Bahrami; Kaja Nordengen; Alexey A. Shadrin; Oleksandr Frei; Dennis van der Meer; Anders M. Dale; Lars T. Westlye; Ole A. Andreassen; Tobias Kaufmann

doi:10.1038/s41467-022-31086-w

Nature Communications (Jun 2022)

Distributed genetic architecture across the hippocampal formation implies common neuropathology across brain disorders

Shahram Bahrami,
Kaja Nordengen,
Alexey A. Shadrin,
Oleksandr Frei,
Dennis van der Meer,
Anders M. Dale,
Lars T. Westlye,
Ole A. Andreassen,
Tobias Kaufmann

Affiliations

Shahram Bahrami: Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
Kaja Nordengen: Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
Alexey A. Shadrin: Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
Oleksandr Frei: Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
Dennis van der Meer: Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
Anders M. Dale: Department of Radiology, School of Medicine, University of California
Lars T. Westlye: Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
Ole A. Andreassen: Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
Tobias Kaufmann: Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo

DOI: https://doi.org/10.1038/s41467-022-31086-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 9

Abstract

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The hippocampus has been associated with memory traits and a variety of neurodegenerative and psychiatric disorders. Here, the authors have done a multivariate GWAS revealing 177 genetic loci, and overlap with various brain disorders may suggest partly age- and disorder-independent mechanisms underlying hippocampal pathology.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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