Nature Communications (Mar 2017)
H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis
- Xian Zhang,
- Binkui Li,
- Abdol Hossein Rezaeian,
- Xiaohong Xu,
- Ping-Chieh Chou,
- Guoxiang Jin,
- Fei Han,
- Bo-Syong Pan,
- Chi-Yun Wang,
- Jie Long,
- Anmei Zhang,
- Chih-Yang Huang,
- Fuu-Jen Tsai,
- Chang-Hai Tsai,
- Christopher Logothetis,
- Hui-Kuan Lin
Affiliations
- Xian Zhang
- Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA
- Binkui Li
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Abdol Hossein Rezaeian
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Xiaohong Xu
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Ping-Chieh Chou
- Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA
- Guoxiang Jin
- Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA
- Fei Han
- Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA
- Bo-Syong Pan
- Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA
- Chi-Yun Wang
- Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA
- Jie Long
- Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA
- Anmei Zhang
- Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA
- Chih-Yang Huang
- Graduate Institute of Basic Medical Science, China Medical University
- Fuu-Jen Tsai
- College of Chinese Medicine, China Medical University
- Chang-Hai Tsai
- Department of Biotechnology, Asia University
- Christopher Logothetis
- Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center
- Hui-Kuan Lin
- Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA
- DOI
- https://doi.org/10.1038/ncomms14799
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
Histone modifications play important roles in gene transcription and cancer. Here the authors establish a role for the E3 ubiquitin ligase NEDD4 in modifying in a glucose-dependent manner the histone H3, thus regulating the expression of genes involved in tumorigenesis.
