Nature Communications (Feb 2018)
Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma
- Melanie Werner-Klein,
- Sebastian Scheitler,
- Martin Hoffmann,
- Isabelle Hodak,
- Klaus Dietz,
- Petra Lehnert,
- Veronika Naimer,
- Bernhard Polzer,
- Steffi Treitschke,
- Christian Werno,
- Aleksandra Markiewicz,
- Kathrin Weidele,
- Zbigniew Czyz,
- Ulrich Hohenleutner,
- Christian Hafner,
- Sebastian Haferkamp,
- Mark Berneburg,
- Petra Rümmele,
- Anja Ulmer,
- Christoph A. Klein
Affiliations
- Melanie Werner-Klein
- Experimental Medicine and Therapy Research, University of Regensburg
- Sebastian Scheitler
- Experimental Medicine and Therapy Research, University of Regensburg
- Martin Hoffmann
- Division of Personalized Tumor Therapy, Fraunhofer-Institute for Toxicology and Experimental Medicine
- Isabelle Hodak
- Experimental Medicine and Therapy Research, University of Regensburg
- Klaus Dietz
- Department of Medical Biometry, University of Tübingen
- Petra Lehnert
- Department of Dermatology, University of Tübingen
- Veronika Naimer
- Experimental Medicine and Therapy Research, University of Regensburg
- Bernhard Polzer
- Division of Personalized Tumor Therapy, Fraunhofer-Institute for Toxicology and Experimental Medicine
- Steffi Treitschke
- Division of Personalized Tumor Therapy, Fraunhofer-Institute for Toxicology and Experimental Medicine
- Christian Werno
- Division of Personalized Tumor Therapy, Fraunhofer-Institute for Toxicology and Experimental Medicine
- Aleksandra Markiewicz
- Experimental Medicine and Therapy Research, University of Regensburg
- Kathrin Weidele
- Division of Personalized Tumor Therapy, Fraunhofer-Institute for Toxicology and Experimental Medicine
- Zbigniew Czyz
- Division of Personalized Tumor Therapy, Fraunhofer-Institute for Toxicology and Experimental Medicine
- Ulrich Hohenleutner
- Department of Dermatology, University of Regensburg
- Christian Hafner
- Department of Dermatology, University of Regensburg
- Sebastian Haferkamp
- Department of Dermatology, University of Regensburg
- Mark Berneburg
- Department of Dermatology, University of Regensburg
- Petra Rümmele
- Department of Pathology, University of Regensburg
- Anja Ulmer
- Department of Dermatology, University of Tübingen
- Christoph A. Klein
- Experimental Medicine and Therapy Research, University of Regensburg
- DOI
- https://doi.org/10.1038/s41467-017-02674-y
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
For several cancer types, mouse models indicate that metastasis occurs early. Here, the authors show that human melanoma cells disseminate early and illustrate a genetic colonisation signature that evolves in parallel at different sites.
