Memorias do Instituto Oswaldo Cruz (May 2006)

Complete genetic characterization of a Brazilian dengue virus type 3 strain isolated from a fatal outcome

  • Marize Pereira Miagostovich,
  • Flávia Barreto dos Santos,
  • Túlio Machado Fumian,
  • Flávia Ramos Guimarães,
  • Eliane Veiga da Costa,
  • Fernando Neto Tavares,
  • Janice Oliveira Coelho,
  • Rita Maria Ribeiro Nogueira

DOI
https://doi.org/10.1590/S0074-02762006000300015
Journal volume & issue
Vol. 101, no. 3
pp. 307 – 313

Abstract

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We have determined the complete nucleotide and the deduced amino acid sequences of Brazilian dengue virus type 3 (DENV-3) from a dengue case with fatal outcome, which occurred during an epidemic in the state of Rio de Janeiro, Brazil, in 2002. This constitutes the first complete genetic characterization of a Brazilian DENV-3 strain since its introduction into the country in 2001. DENV-3 was responsible for the most severe dengue epidemic in the state, based on the highest number of reported cases and on the severity of clinical manifestations and deaths reported.

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