Synthesis of difluoromethylated allenes through trifunctionalization of 1,3-enynes

Munira Taj Muhammad; Yihang Jiao; Changqing Ye; Mong-Feng Chiou; Muhammad Israr; Xiaotao Zhu; Yajun Li; Zhenhai Wen; Armido Studer; Hongli Bao

doi:10.1038/s41467-019-14254-3

Nature Communications (Jan 2020)

Synthesis of difluoromethylated allenes through trifunctionalization of 1,3-enynes

Munira Taj Muhammad,
Yihang Jiao,
Changqing Ye,
Mong-Feng Chiou,
Muhammad Israr,
Xiaotao Zhu,
Yajun Li,
Zhenhai Wen,
Armido Studer,
Hongli Bao

Affiliations

Munira Taj Muhammad: State Key Laboratory of Structural Chemistry, Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, University of Chinese Academy of Sciences
Yihang Jiao: State Key Laboratory of Structural Chemistry, Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, University of Chinese Academy of Sciences
Changqing Ye: State Key Laboratory of Structural Chemistry, Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, University of Chinese Academy of Sciences
Mong-Feng Chiou: State Key Laboratory of Structural Chemistry, Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, University of Chinese Academy of Sciences
Muhammad Israr: State Key Laboratory of Structural Chemistry, Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, University of Chinese Academy of Sciences
Xiaotao Zhu: State Key Laboratory of Structural Chemistry, Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, University of Chinese Academy of Sciences
Yajun Li: State Key Laboratory of Structural Chemistry, Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, University of Chinese Academy of Sciences
Zhenhai Wen: State Key Laboratory of Structural Chemistry, Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, University of Chinese Academy of Sciences
Armido Studer: Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Corrensstraße 40
Hongli Bao: State Key Laboratory of Structural Chemistry, Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, University of Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-019-14254-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 8

Abstract

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Fluorinated or fluoroalkylated allenes are versatile building blocks for medicinal and material chemistry. Here, the authors show a regioselective trifunctionalization of 1,3-enynes proceeding through double C-F bond formation and concomitant installation of a -NSO2Ph group to the allene moiety.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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