Effect of Convallaria majalis on Kidney Function

Abstract

Objective: To evaluate the effect o f Convallaria majalis on kidney function. The kidneys are vital organs thatperform a variety of important functions in our body. Primary and secondary causes o f kidney diseases producechanges in glomerular filtration rate that m ay leads to kidney failure. Blood parameters such as uric acid andcreatinine are used to assess kidney function. C. majalis (CM) commonly called as Lily o f the valley is aHomoeopathic remedy having valuable action on heart and also has diuretic action. Methods: In the present study, the effect o f CM was investigated on serum uric acid and creatinine, byadministrating orally 70% alcoholic extract o f CM (10 and 50 mg/kg), simvastatin (20 mg/kg), 0.05%dimethylsulphooxide (DMSO, 1ml/kg) and distilled w ater (1ml/kg) to test (A & B groups), positive, negativeand control rabbits respectively for 14 days consecutively once in a day. On completion o f trial, rabbits weresac rificed to co llec t b lo o d and serum was sep a rated to estimate uric acid and creatin in e levels. Results: Out of two tested doses, 10 mg/kg o f CM produced significant decrease in uric acid levels from 10.978.40mg/dL in test rabbits (Test A) when compared with control, negative & positive control groups (p<0.05).However, the same dose o f extract showed no effect on serum creatinine levels. Whereas alcoholic extract @50 m g/kg was found in e ffe c tiv e in red u c in g e ith e r o f serum u ric ac id and c re a tin in e lev els. Conclusion: According to the data, alcoholic extract o f CM @ 10mg/kg was found as a significant hypouricemicagent.

Keywords

• glomerular filtration
• kidney
• uric acid
• creatinine
• hypouricemic activity