Nature Communications (Apr 2018)
NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network
- David J. Anderson,
- David I. Kaplan,
- Katrina M. Bell,
- Katerina Koutsis,
- John M. Haynes,
- Richard J. Mills,
- Dean G. Phelan,
- Elizabeth L. Qian,
- Ana Rita Leitoguinho,
- Deevina Arasaratnam,
- Tanya Labonne,
- Elizabeth S. Ng,
- Richard P. Davis,
- Simona Casini,
- Robert Passier,
- James E. Hudson,
- Enzo R. Porrello,
- Mauro W. Costa,
- Arash Rafii,
- Clare L. Curl,
- Lea M. Delbridge,
- Richard P. Harvey,
- Alicia Oshlack,
- Michael M. Cheung,
- Christine L. Mummery,
- Stephen Petrou,
- Andrew G. Elefanty,
- Edouard G. Stanley,
- David A. Elliott
Affiliations
- David J. Anderson
- Murdoch Childrens Research Institute, Royal Children’s Hospital
- David I. Kaplan
- The Florey Institute of Neuroscience and Mental Health; Centre for Neuroscience, University of Melbourne
- Katrina M. Bell
- Murdoch Childrens Research Institute, Royal Children’s Hospital
- Katerina Koutsis
- Murdoch Childrens Research Institute, Royal Children’s Hospital
- John M. Haynes
- Monash Institute of Pharmaceutical Science, Monash University
- Richard J. Mills
- School of Biomedical Sciences, University of Queensland
- Dean G. Phelan
- Murdoch Childrens Research Institute, Royal Children’s Hospital
- Elizabeth L. Qian
- Murdoch Childrens Research Institute, Royal Children’s Hospital
- Ana Rita Leitoguinho
- Murdoch Childrens Research Institute, Royal Children’s Hospital
- Deevina Arasaratnam
- Murdoch Childrens Research Institute, Royal Children’s Hospital
- Tanya Labonne
- Murdoch Childrens Research Institute, Royal Children’s Hospital
- Elizabeth S. Ng
- Murdoch Childrens Research Institute, Royal Children’s Hospital
- Richard P. Davis
- Department of Anatomy and Embryology, Leiden University Medical Center
- Simona Casini
- Department of Anatomy and Embryology, Leiden University Medical Center
- Robert Passier
- Department of Anatomy and Embryology, Leiden University Medical Center
- James E. Hudson
- School of Biomedical Sciences, University of Queensland
- Enzo R. Porrello
- School of Biomedical Sciences, University of Queensland
- Mauro W. Costa
- The Jackson Laboratory
- Arash Rafii
- Stem Cell and Microenvironment Laboratory, Weill Cornell Medical College in Qatar Qatar Foundation
- Clare L. Curl
- Department of Physiology, University of Melbourne
- Lea M. Delbridge
- Department of Physiology, University of Melbourne
- Richard P. Harvey
- Victor Chang Cardiac Research Institute
- Alicia Oshlack
- Murdoch Childrens Research Institute, Royal Children’s Hospital
- Michael M. Cheung
- Murdoch Childrens Research Institute, Royal Children’s Hospital
- Christine L. Mummery
- Department of Anatomy and Embryology, Leiden University Medical Center
- Stephen Petrou
- The Florey Institute of Neuroscience and Mental Health; Centre for Neuroscience, University of Melbourne
- Andrew G. Elefanty
- Murdoch Childrens Research Institute, Royal Children’s Hospital
- Edouard G. Stanley
- Murdoch Childrens Research Institute, Royal Children’s Hospital
- David A. Elliott
- Murdoch Childrens Research Institute, Royal Children’s Hospital
- DOI
- https://doi.org/10.1038/s41467-018-03714-x
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
A gene regulatory network, including the transcription factor Nkx2-5, regulates cardiac development. Here, the authors show that on deletion of NKX2-5 from human embryonic stem cells, there is impaired cardiomyogenesis and changes in action potentials, and that this is regulated via HEY2.
