Nature Communications (Apr 2019)

Characterizing pre-transplant and post-transplant kidney rejection risk by B cell immune repertoire sequencing

  • Silvia Pineda,
  • Tara K. Sigdel,
  • Juliane M. Liberto,
  • Flavio Vincenti,
  • Marina Sirota,
  • Minnie M. Sarwal

DOI
https://doi.org/10.1038/s41467-019-09930-3
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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Adaptive immunity from both B and T cells critically controls the rejection or survival of transplanted organs. Here the authors show, by analyzing human B cell receptor repertoire in longitudinal studies of patients receiving kidney transplants, that repertoire diversity is positively associated with the incidence of kidney rejection.